Thymocyte Maturation in AKR Leukemia
The central role played by the thymus during leukemogenesis in the AKR mouse is well established (1, 2). The AKR mouse develops lymphocytic lymphoma and leukemia with an incidence of 90% (2). Although this strain is infected with gross virus prior to birth, manifestations of the disease are not apparent until six months of age (3). Therefore, there appears to be a latent period before the onset of thymoma in these animals. The intrathymic events during this latent period are of prime importance since neonatal thymectomy reduces the incidence of leukemia (4).
KeywordsThymus Epithelium Neonatal Thymectomy Thymocyte Maturation Glass Wool Filter Mitogen Concanavalin
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