Advertisement

Thymocyte Maturation in AKR Leukemia

  • S. D. Waksal
  • S. Smolinsky
  • I. R. Cohen
  • R. L. St. Pierre
  • M. Feldman

Abstract

The central role played by the thymus during leukemogenesis in the AKR mouse is well established (1, 2). The AKR mouse develops lymphocytic lymphoma and leukemia with an incidence of 90% (2). Although this strain is infected with gross virus prior to birth, manifestations of the disease are not apparent until six months of age (3). Therefore, there appears to be a latent period before the onset of thymoma in these animals. The intrathymic events during this latent period are of prime importance since neonatal thymectomy reduces the incidence of leukemia (4).

Keywords

Thymus Epithelium Neonatal Thymectomy Thymocyte Maturation Glass Wool Filter Mitogen Concanavalin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Miller, J.F.A.P. Nature 191:248, 1961.PubMedCrossRefGoogle Scholar
  2. 2.
    Met calf, D. The Thymus, Recent Results in Cancer Research, Vol. 5, Springer-Verlag, Inc., New York, 1966.Google Scholar
  3. 3.
    Gross, L. Proc. Soc. Exp. Biol. Med., 78:342, 1951.Google Scholar
  4. 4.
    Miller, J.F.A.P. Br. J. Cancer 14:93, 1960.PubMedCrossRefGoogle Scholar
  5. 5.
    Raff, M.C. and Wortis, H.H. Immunology 18:931, 1970.PubMedGoogle Scholar
  6. 6.
    Weissman, I.L., Small, M., Fathman, C.G. and Herzenberg, L.A. Fed. Proc., 34:143, 1975.Google Scholar
  7. 7.
    Waksal, S.D., R.L. St. Pierre, J.R. Hostetler, and R.M. Folk. Cell. Immunol., 12:66, 1974.PubMedCrossRefGoogle Scholar
  8. 8.
    Gorer, P.A. and O’Gorman, P. Transplant. Bull., 3:142, 1956.Google Scholar
  9. 9.
    Metcalf, D. J. Nat. Cancer Inst., 37:425, 1966.Google Scholar
  10. 10.
    Barker, A.D. and Waksal, S.D. Cell. Immunol., 12:140, 1974.PubMedCrossRefGoogle Scholar
  11. 11.
    Waksal, S.D., Cohen, I.R., Waksal, H.W., St. Pierre, R.L Feldman, M. Ann. N.Y. Acad. Sei., 249:492, 1975.CrossRefGoogle Scholar
  12. 12.
    Auerbach, R. IN: Epithelial Mesechymal Interactions. (R. Fleischmaj er and R. G. Billingham, eds.), p. 200, 1968.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • S. D. Waksal
    • 1
    • 2
  • S. Smolinsky
    • 1
    • 2
  • I. R. Cohen
    • 1
    • 2
  • R. L. St. Pierre
    • 1
    • 2
  • M. Feldman
    • 1
    • 2
  1. 1.Weizmann Institute of ScienceOhio State UniversityRehovotIsrael
  2. 2.Weizmann Institute of ScienceOhio State UniversityColumbusUSA

Personalised recommendations