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Clinical, Immunological and Histopathological Evidence for Thymic Deficiency in Down’s Syndrome (Mongolism)

  • M. Schlesinger
  • S. Levin
  • Z. Handzel
  • T. Hahn
  • Y. Altman
  • B. Chernobilski
  • J. Bos

Abstract

Down’s syndrome (DS) is a chromosomal disorder leading to genetic malformations of various systems, the most marked giving rise to mental retardation and skeletal and heart abnormalities. The incidence of this disorder ranges from 1 per 1000 births in young mothers, to 1 per 50 births in mothers over 40 years of age. Certain clinical observations have recently lead investigators to study the immune system in DS.

Keywords

Lymphocyte Depletion Hadassah Medical School Reticular Epithelial Cell Mixed Leucocyte Reaction Genetic Malformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • M. Schlesinger
    • 1
  • S. Levin
    • 1
  • Z. Handzel
    • 1
  • T. Hahn
    • 1
  • Y. Altman
    • 1
  • B. Chernobilski
    • 2
  • J. Bos
    • 3
  1. 1.The Pediatric Research Dept.Hebrew University — Hadassa Medical SchoolJerusalemIsrael
  2. 2.Pathology Dept.Hebrew University — Hadassa Medical SchoolJerusalemIsrael
  3. 3.Kaplan Hospital, Rehovot and Pathology DeptHebrew University — Hadassa Medical SchoolJerusalemIsrael

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