Involvement of Cells With ‘B’ Properties in Development of T Helpers
The question as to whether T and B cell populations develop independently of each other, or whether they represent different stages of differentiation within the same cell lineage is so far unresolved. During ontogeny, T and B cells differentiate in different compartments (1). However, this distinction is not entirely clear cut. Mouse embryonic liver, which is supposedly a territory of B cell development (2, 3) may give rise to cells with T properties upon treatment with thymic factors, as expressed in reactivity in a GvH response (4) or expression of membrane markers (5). The question is thus raised as to whether the embryonic liver contains cells which are uncommitted, and the pathways of development can be imposed by effects of micro-environmental or humoral factors, or whether cells with T properties develop from cells which already express B characteristics.
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