Differentiation and Ontogeny of Lymphoid Cells

  • N. L. Warner


For many years it has been recognised that lymphocytes play a central role in the initiation and development of both cellular and humoral immunity. In considering the heterogeneous nature of specific immune responses it was proposed from studies in birds1 that there were two distinct lymphoid cell differentiation pathways, in that the bursa of Fabricius controlled the development of cells of the antibody forming series, whereas the thymus controlled the differentiation of lymphoid cells involved in cellular immunity. With the subsequent development of the concept of cell interactions in immune responses2, 3 the specific roles of bone marrow derived cells, (termed B cells, implying either bursal equivalent derivation) and T cells, in production of antibody were clearly defined. The subsequent application of a variety of cell surface markers and receptors to the analysis of distinct populations of lymphoid cells has even further validated the concept of two broad streams of lymphocyte differentiation represented under the general groupings of T and B lymphocytes. In this presentation I would like to concentrate on several of the current problems relating to the differentiation and ontogeny of T and B lymphocytes.


Hematopoietic Stem Cell Lymphoid Cell Inductive Stimulus Primary Lymphoid Organ Antigen Specific Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Warner, N.L., Szenberg, A. and Burnet, F.M., Aust.J.Exp. Biol., 40, 373, 1962.CrossRefGoogle Scholar
  2. 2.
    Claman, H.N. and Chaperon, E.A., Transpl. Rev., 1, 92, 1969.Google Scholar
  3. 3.
    Miller, J.F.A.P. and Mitchell, G.F., Transpl. Rev., 1, 3,1969.Google Scholar
  4. 4.
    Metcalf, D. and Moore, M.A.S., “Hemopoietic cells: Their origin, migration and differentiation”. North-Holland, 1971.Google Scholar
  5. 5.
    El-Arini, M.O. and Osoba, D., J.Exp.Med., 137, 821, 1973.PubMedCrossRefGoogle Scholar
  6. 6.
    Lafleur, L., Miller, R.G. and Phillips, R.A., J.Exp.Med., 137, 1363, 1972.CrossRefGoogle Scholar
  7. 7.
    Lawton, A.R., Kincade, P.W. and Cooper, M.D., Fed.Proc. 34, 33, 1975.PubMedGoogle Scholar
  8. 8.
    Owen, J.J.T., Cooper, M.D. and Raff, M.C., Nature, 249, 361, 1974.PubMedCrossRefGoogle Scholar
  9. 9.
    Osmond, D.G. and Nossal, G.J.V., Cell Immunol., 13, 117, 1974.PubMedCrossRefGoogle Scholar
  10. 10.
    Ryser, J.E. and Vassalli, P., J.Immunol., 113, 719, 1974.PubMedGoogle Scholar
  11. 11.
    Warner, N.L., Advances Immunol., 19, 67, 1974.CrossRefGoogle Scholar
  12. 12.
    Jones, P.P., Craig, S.W., Cebra, J.J. and Herzenberg, C.A J.Exp.Med., 140, 452, 1974.PubMedCrossRefGoogle Scholar
  13. 13.
    Rowe, D.S., Hug, K., Forni, L. and Pernis, B., J. Exp. Med. 138, 965, 1973.PubMedCrossRefGoogle Scholar
  14. 14.
    Seligmann, M., Preud’homme, J.L. and Kourilsky, F.M. (Editors) Membrane receptors of lymphocytes, in press, 1975.Google Scholar
  15. 15.
    Klinman, N.R. and Press, J.L., Fed.Proc., 34, 47, 1975.PubMedGoogle Scholar
  16. 16.
    Silverstein, A.M. and Segal, S. this volume.Google Scholar
  17. 17.
    Miller, A., Duca, D., Celada, F. and Sercarz, E. this volume.Google Scholar
  18. 18.
    Nussenzweig, V., Advances Immunol., 19, 217, 1974.CrossRefGoogle Scholar
  19. 19.
    Warner, N.L., Potter, M. and Metcalf, D. (Eds) U.I. C. C. Technical report series, Vol 13, 1974.Google Scholar
  20. 20.
    Shortman, K. and Jackson, H., Cell Immunol., 12, 230, 1974.PubMedCrossRefGoogle Scholar
  21. 21.
    Broder, S., Humphrey, R., Durm, M., Blackman, M., Meade, B. and Waldmann, T., Fed.Proc., 34, 1003, 1975Google Scholar
  22. 22.
    Warner, N.L. and Anderson, R.E., Nature, 254, 604, 1975.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • N. L. Warner
    • 1
  1. 1.Genetics Unit, The Walter & Eliza Hall InstituteRoyal Melbourne HospitalAustralia

Personalised recommendations