Chemotherapy pp 405-411 | Cite as

Animal and Human Studies with Oral Mitomycin C(6): A Preliminary Report

  • P. D. Boasberg
  • T. C. Hall
  • O. O. Odujinrin
  • R. S. Benjamin
  • B. B. Lowitz
  • H. B. Nevinny
  • Charlotte L. Maddock
Part of the Chemotherapy book series (CT, volume 8)

Abstract

Mitomycin C, a product of Streptomyces caespetosus, is an antineoplastic antibiotic marketed for intravenous usage (1). Extravasation outside the vein at the site of the injection results in painful necrosis of the surrounding tissue, and daily intravenous injections are a difficult method to use when continuous low dose therapy is desired. Consideration was given to the development of an oral form of Mitomycin C. This paper reports results from our initial animal and human trials. We later learned that oral Mitomycin C has been used clinically in Japan.

Keywords

Toxicity Adenocarcinoma Bicarbonate Peri Streptomyces 

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References

  1. 1.
    Carter, S.K. (1968), Mitomycin C (NSC-26980)-Clinical Brochure Cancer Chemotherapy Reports, Part 3, Vol. 1., 99–104.Google Scholar
  2. 2.
    Philips, F.S., Schwartz, H.S. and Sternberg, S.S. (1960). Pharmacology of Mitomycin C. I. Toxicity and Pathologic Effects. Cancer Research, 20, 1354–1361.PubMedGoogle Scholar
  3. 3.
    Whittington, R.M. and Close, H.P. (1970). Clinical Experience with Mitomycin C. (NSC-26980) — Cancer Chemotherapy Reports, Part 1, Vol. 51., 195–198, No. 3.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • P. D. Boasberg
    • 1
  • T. C. Hall
    • 1
    • 2
    • 3
  • O. O. Odujinrin
    • 1
  • R. S. Benjamin
    • 1
  • B. B. Lowitz
    • 1
  • H. B. Nevinny
    • 3
  • Charlotte L. Maddock
    • 3
  1. 1.Los Angeles County-University of Southern California Cancer CenterUSA
  2. 2.University of Rochester, School of MedicineUSA
  3. 3.Children’s Cancer Research FoundationUSA

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