Chemotherapy pp 269-274 | Cite as

Clinical Studies on Changes in Serum Glycoproteins in Cancer Chemotherapy

  • Kunihiro Funahashi
  • R. Esaki
  • J. Hayashi
  • T. Itoh
  • K. Shibata
Part of the Chemotherapy book series (CT, volume 8)

Abstract

Serum glycoproteins of patients with cancer(α1 — Acidglycoprotein, α1 -Antitrypsin, α2-Haptoglobin, α2-Ceruloplasmin) were determined with the Immunoassay Partigen method and the values were observed to be remarkably higher than those patients with benign diseases. Further, it was noted that these values tended to increase with the progress of tumor. Accordingly, it was considered that the progress of cancer could be comprehended objectively through the changes of the values of serum glycoproteins and that these changes might be helpful for the evalation of the effect of anticancer agents administered. Besides, these serum glycoproteins might be a material coating lymphocytes, closely associated with immunoinsufficiency found in patients with cancer. The number of cancer patients examined was 108 in total, which included 33 cases of stomach cancer, 33 cases of colon and rectal cancer, 22 cases of liver, biliary and pancreatic cancer, 8 cases of breast cancer, 5 cases of lung cancer, 6 cases of malignant lymphoma. On the other hand, the benign diseases included 14 cases of gastric, duodenal and cholelithiasis. Classification of the changes of values of alpha,-AG by the disease revealed that in benign diseases they ranged between 40 to 70 mg/dl, remaining almost normal, while in the case of stomach cancer, colon and rectal cancer, they showed a stairlike increase in accordance with the groups aggravating from radical operation group ( A ), palliative operation’s group ( B ) and inoperable cases ( C ).

Keywords

Lymphoma Glyco Cholelithiasis 

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References

  1. 1).
    Esaki, R. et al. Activity on Cancer Cells and Distribution in Tissue of Anticancer Drugs. II,334,1970. Tokyo.Google Scholar
  2. 2).
    Esaki, R. et al.Sensitivity of Anticancer Drugs and Their Concentration in Tissues. Advances in Antimicrobial and Antineoplastic Chemotherapy.II.383,1972.Praha.Google Scholar
  3. 3).
    Surgery and Chemotherapy in Children with Malignant Neoplasmas: With Special Reference to Drug Sensitivity and Drug Concentration in Tumor Tissues. Progress in Chemotherapy.III.637,1974.Athens.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Kunihiro Funahashi
    • 1
  • R. Esaki
    • 1
  • J. Hayashi
    • 1
  • T. Itoh
    • 1
  • K. Shibata
    • 1
  1. 1.The First Department of SurgeryNagoya City University Medical SchoolMizuho, NagoyaJapan

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