Chemotherapy pp 159-164 | Cite as

Clinical Cancer Chemotherapy with Drugs Aimed at Gene Regulators

  • F. E. Knock
  • R. M. Galt
  • Y. T. Oester
  • R. Sylvester
Part of the Chemotherapy book series (CT, volume 8)

Abstract

Clinically useful sulfhydryl (SH) inhibitors appear to show preferential toxicity against a variety of animal and human cancers, relative to normal tissues. Such preferential effects have been seen both in vivo and by in vitro sensitivity tests.1–9

Keywords

Toxicity Fluoride Heparin Electrophoresis Polyacrylamide 

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References

  1. 1.
    Szent-Gyorgyi, A., Bioelectronics, Academic Press, New York, 1968, pp. 75–89.Google Scholar
  2. 2.
    Knock, F.E.,Arch. Surg., 86 (1963) 489.Google Scholar
  3. 3.
    KnockfF. E.,J. Am. Med.Assoc.197 (1966) 151.Google Scholar
  4. 4.
    Knock, F.E.,J. Am. Geriatrics Soc.,14 (1966)883;15(1967),882.Google Scholar
  5. 5.
    Knock, F.E.,Perspectives Biol. Med. 10 (1967) 310.Google Scholar
  6. 6.
    KnocktF. F.E..Anticancer Agents,Charles C. Thomas, Springfield,1967, pp. 93,122,166,183,213.Google Scholar
  7. 7.
    Knock, F.E., Natl.Cancer Inst.Mono.,34 (1972)247.Google Scholar
  8. 8.
    Knock, F.E., Gait, R.M., Oester, Y.T., Sylvester, R.,Oncology, 26 (1972),515.PubMedCrossRefGoogle Scholar
  9. 9.
    Knock, F.E., Gait, R.M. Oester, Y.T., Sylvester, R.,Oncology, 30 (1974) 1.PubMedCrossRefGoogle Scholar
  10. 10.
    Black, M.M., Kleiner, I.S. and Bolker, H., Cancer Res.,7(1947)818.PubMedGoogle Scholar
  11. 11.
    Stellwagon, R., and Cole, H., Annu.Rev. Biochem,38 (1969) 951.CrossRefGoogle Scholar
  12. 12.
    Gilmour, R.S. and Paul, J., FEBS Letters 9 (1970) 242.PubMedCrossRefGoogle Scholar
  13. 13.
    Teng, C., Teng, C. and Allfrey, V.G., J. Biol.Chem,246(1971)3597.PubMedGoogle Scholar
  14. 14.
    Spelsberg, T.C. and Hnilica. L., Biochem. J., 120 (1970) 435.PubMedGoogle Scholar
  15. 15.
    Stein, G.S. and Farber, J., Proc. Natl. Acad. Sci. 69 (1972)2918.PubMedCrossRefGoogle Scholar
  16. 16.
    Stein, G.S., Spelsberg, T.C. and Kleinsmith, L.J., Science,183, (1974)817.PubMedCrossRefGoogle Scholar
  17. 17.
    Chae, C., et al, Cancer Res., 30 (1970) 2652.PubMedGoogle Scholar
  18. 18.
    Stein, G.S. and Thrall, C.L., FEBS Letters, 34 (1973) 35.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • F. E. Knock
    • 1
  • R. M. Galt
    • 1
  • Y. T. Oester
    • 1
  • R. Sylvester
    • 1
  1. 1.Augustana HospitalUniversity of Illinois, Loyola Univ.ChicagoUSA

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