Oestrogen Binding as a Predictive Test for DMBA-Induced Tumour Response to Tamoxifen Therapy

  • V.C. Jordan
  • T. Jaspan

Abstract

Jensen et al, (1971) have suggested that oestrogen receptor assays may be a useful predictive test to determine the oestrogen dependency of breast tumours. In the laboratory, the 7,12dimethylbenz(a)anthracene (MBA)-induced rat mammary carcinoma (Huggins et al. 1961) provides a model for the study of this theory, since oestrogen binding in the tumour has been reported to be related to oestrogen dependency (Mobbs 1966, McGuire & Julian 1971, Mobbs & Johnson 1974).

Keywords

Tamoxifen Oestradiol Cytosol Prolactin Anthracene 

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • V.C. Jordan
    • 1
  • T. Jaspan
    • 1
  1. 1.Department of PharmacologySchool of MedicineLeedsUK

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