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Chemotherapy pp 285-288 | Cite as

Effect of CCNU on Survival, Objective Remissions and Free Interval in Patients with Malignant Gliomas

  • EORTC Brain Tumor Group, presented by L.Calliauw

Abstract

Three nitrosourea derivatives have been shown to be active against malignant brain glioma. The EORTC Brain Tumor Group is concerned with the therapeutic effects of one of them — CCNU (1-2-chloroethyl-3-cyclohexyl-l-nitro-sourea) — on three clinical parameters; total survival time, objective remission rates and free interval between surgery and relapse. To meet the difficulties encountered in measuring these different criteria two parallel trials uere performed. The aim of trial 26741 was to study the rate of objective remissions and free interval, the purpose of trial 26742 was to measure the effect of CCNU on survival time.

Keywords

Survival Time Clinical Parameter Malignant Glioma Supportive Therapy Free Interval 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • EORTC Brain Tumor Group, presented by L.Calliauw
    • 1
  1. 1.Department of NeurosurgerySaint Jans HospitalBruggeBelgium

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