Abstract
Patients with cancer of the breast frequently develop abnormalities of calcium metabolism which sometimes result in death. These abnormalities are usually associated with osteolytic bone metastases and are mainly caused by excessive mobilisation of skeletal calcium. This raises the possibility that the mobilisation of skeletal calcium and erosion of bone to provide space for tumour growth may depend on the production of osteolytically active substances either by tumour cells or as a result of interactions between tumour and host cells.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Reynolds, J.J. (1968). Proc. Roy. Soc. B. 170, 61
Robertson, R.P. and Baylink, R. (1975). Clin. Res. 23, 329A
Seyberth, H.W., Morgan, J.L., Sweetman, B.J. and Oates, J.A. (1975). Clin. Res. 23, 423A
Plescia, O.J., Smith, A.H. and Grinwich, K. (1975). Proc. Nat. Acad. Sci. U.S.A. 72, 1848
Strausser, H.R. and Humes, J.L. (1975). Int. J. Cancer, 15, 724
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Plenum Press, New York
About this chapter
Cite this chapter
Easty, G.C., Powles, T.J., Dowsett, M., Easty, D.M., Neville, A.M. (1976). The Production of Osteolytic Substances by Human Breast Tumours. In: Hellmann, K., Connors, T.A. (eds) Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4349-3_25
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4349-3_25
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4351-6
Online ISBN: 978-1-4613-4349-3
eBook Packages: Springer Book Archive