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Chemotherapy pp 385-390 | Cite as

Sulfametopyrazine as Treatment for Bacteriuria in Pregnancy, and Effects on Bowel Flora

  • D. S. Reeves

Abstract

Sulfametopyrazine (2-sulfanilinamido-3-methoxypyrazine; SMP) is an ultra long-acting sulphonamide. It is the only sulphonamide available in the U.K. with which therapeutically adequate blood levels of drug are maintained for up to a week following a single dose. In patients with asymptomatic infections as bacteriuria in pregnancy this represents an advantage since it is possible for a patient to forget to take some or all of the doses in a multi-dose regime in the absence of symptoms. The importance of treating bacteriuria in pregnancy while the infection remains asymptomatic is well established. The use of a single dose of SMP (2 grams) as treatment for such patients has been already reported (Reeves, 1975), where the development of a two-dose regime of SMP is also described. Reported here are the comparative results of treating bacteriuria in pregnancy with SMP (2 grams), SMP (2+2 grams), or sulphadimidine (SD, in full dosage).

Keywords

Faecal Flora Plate Dilution Technique Bowel Flora Agar Plate Dilution SOUTHMEAD Hospital 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • D. S. Reeves
    • 1
  1. 1.Department of Medical MicrobiologySouthmead HospitalBristolEngland

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