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Chemotherapy pp 195-200 | Cite as

Lincomycin Bone Concentrations During Total Hip Replacement

  • R. L. Parsons
  • J. P. Beavis
  • G. M. Paddock
  • G. M. Hossack

Abstract

Empirical antibiotic regimes given during total hip replacement (THR) are now widely used by most orthopaedic units to reduce the incidence of postoperative infections. In an elderly patient who has already under gone one operation, an infection is a therapeutic disaster since it requires a second operation to remove the prosthesis in a patient who is already debilitated, and therefore at risk. Thus, it is of the utmost importance that the antibiotics used are shown to provide adequate concentrations in bone.

Keywords

Synovial Fluid Bone Sample Drain Fluid Dipotassium Hydrogen Dipotassium Hydrogen Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1).
    Grove, D.C. & Randall, W.A. Assay methods of antibiotics: A laboratory manual. Medical Encyclopedia Inc. New York (1955).Google Scholar
  2. 2).
    Garrod, L.P., Lambert, H.P. & O’Grady, F.O. Antibiotic & Chemotherapy, 4th ed. p. 207. (1973). Churchill Livingstone, Edinburgh & London.Google Scholar
  3. 3).
    Parsons, R.L,, Salfield, J. & Beavis, J.P. Antibiotic induced diarrhoea & colitis in orthopaedic in patients. Proceedings of the 9th International Congress of Chemotherapy. in press (1975).Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • R. L. Parsons
    • 1
  • J. P. Beavis
    • 1
  • G. M. Paddock
    • 1
  • G. M. Hossack
    • 1
  1. 1.Department of Clinical PharmacologyGuy’s Hospital Medical SchoolLondonUK

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