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Stimulation of Adenylate Cyclase in the Thyroid

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Eukaryotic Cell Function and Growth

Abstract

In 1962 Klainer et al. (1) reported the presence of an adenylate cyclase in the thyroid, responsive to the pituitary hormone, TSH1. Since then, research has mainly been directed towards determining the relevance of cyclic AMP as a regulator of the thyroid follicular cell, particularly in response to TSH. However, during the course of this work, many other compounds have been tested as potential stimulators of adenylate cyclase in the thyroid. In this paper, evidence that thyroidal adenylate cyclase can be activated by compounds as diverse as immunoglobulins, prostaglandins and catecholamines as well as TSH will be discussed. It is, as yet, too soon to debate the physiological significance of these responses and discussion is directed towards characterisation of the response to each different group of agonists, and consideration of the influence this might bear on our ultimate concept of the hormone-receptor/membrane adenylate cyclase system(s) operative in the thyroid.

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Abbreviations

TSH:

thyroid stimulation hormone

TSIg:

thyroid stimulating immunoglobulins

PG:

prostaglandin

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Authors and Affiliations

  1. Department of Nuclear Medicine, The Middlesex Hospital Medical School, Thorn Institute of Clinical Science, Mortimer Street, London, W1N 8AA, UK

    N. J. Marshall

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  1. Institute of Interdisciplinary Research, University of Brussels Medical Schools, Brussels, Belgium

    Jacques E. Dumont

  2. Institute of Nuclear Medicine, Thorn Institute of Clinical Sciences, The Middlesex Hospital Medical School, London, UK

    Barry L. Brown  & Nicholas J. Marshall  & 

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Marshall, N.J. (1976). Stimulation of Adenylate Cyclase in the Thyroid. In: Dumont, J.E., Brown, B.L., Marshall, N.J. (eds) Eukaryotic Cell Function and Growth. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4322-6_7

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