Abstract
Fibroblasts grown in monolayer on Petri dishes display various characteristics some of which help one to differentiate normal from malignant cells. For example, malignant fibroblasts, also called “transformed” cells, usually grow faster than their normal counterpart, they do not show density-dependent inhibition of growth, they move more rapidly, adhere less to the substratum, etc. Considering that cAMP mediates the regulation of numerous functions in all kinds of cells, mostly those functions which are characteristic of the differentiated state of a cell line, it was reasonable to hypothesize that cAMP was involved in the expression of those properties in cultured fibroblasts which distinguish normal from malignant cells.
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Abbreviations
- cAMP:
-
3′, 5′ cyclic adenosine monosphate
- Bt2cAMP:
-
N6, O2-dibutyryl cyclic AMP
- CEF:
-
chick embryo fibroblasts
- RSV:
-
Rons sarcoma virus
- RSV-Ts:
-
temperature sensitive mutant of Rons sarcoma virus
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© 1976 Plenum Press, New York
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Otten, J. (1976). Cyclic AMP and Cancer. In: Dumont, J.E., Brown, B.L., Marshall, N.J. (eds) Eukaryotic Cell Function and Growth. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4322-6_39
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DOI: https://doi.org/10.1007/978-1-4613-4322-6_39
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