Role of Cyclic Nucleotides in the Anterior Pituitary Gland

  • B. L. Brown

Abstract

It is now well established that a number of hormones synthesised in the hypothalamic area and carried to their adenohypophyseal site of action by a portal system, act to modulate the release of anterior pituitary hormones. Some of these hypothalamic regulating factors have now been characterised. The first to be demonstrated (1) was corticotrophin releasing factor (CRF); however, its structure is still not known. Thyrotrophin releasing hormone (TRH) was the first hypothalamic factor to be fully characterised, largely through the efforts of two groups led by Guillemin and Schally respectively (2,3) and shown to be a tripeptide (pyroglutamyl-histidyl-proline amide). The synthesis of TRH was closely followed by the identification and synthesis of gonadotrophin releasing hormone (GnRH), a decapeptide which stimulates the release of both LH and FSH.

Keywords

Dopamine Dexamethasone Prostaglandin Oestradiol Prolactin 

Abbreviations

TSH

thyroid stimulating hormone (thyrotrophin)

LH

luteinising hormone

FSH

follicle stimulating hormone

ACTH

Adrenocorticotrophic hormone

GH

growth hormone

TRH

thyrotrophin releasing hormone

GnRH (also LHRH)

Gonadotropin releasing hormone

CRF

corticotrophin releasing factor

GHRH

growth hormone releasing hormone

GHRIH (somatostatin)

growth hormone release inhibiting hormone

PRF

prolactin releasing factor

PIF

Prolactin inhibiting factor

TS

Triiodothyronine

T4

Thyroxine

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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • B. L. Brown
    • 1
  1. 1.Department of Nuclear Medicine, The Middlesex Hospital Medical SchoolThorn Institute of Clinical ScienceLondonUK

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