Role of Cyclic Nucleotides in the Anterior Pituitary Gland

  • B. L. Brown


It is now well established that a number of hormones synthesised in the hypothalamic area and carried to their adenohypophyseal site of action by a portal system, act to modulate the release of anterior pituitary hormones. Some of these hypothalamic regulating factors have now been characterised. The first to be demonstrated (1) was corticotrophin releasing factor (CRF); however, its structure is still not known. Thyrotrophin releasing hormone (TRH) was the first hypothalamic factor to be fully characterised, largely through the efforts of two groups led by Guillemin and Schally respectively (2,3) and shown to be a tripeptide (pyroglutamyl-histidyl-proline amide). The synthesis of TRH was closely followed by the identification and synthesis of gonadotrophin releasing hormone (GnRH), a decapeptide which stimulates the release of both LH and FSH.


Corticotrophin Release Factor Trophin Release Hormone Prolactin Release Hypothalamic Hormone Hypothalamic Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



thyroid stimulating hormone (thyrotrophin)


luteinising hormone


follicle stimulating hormone


Adrenocorticotrophic hormone


growth hormone


thyrotrophin releasing hormone

GnRH (also LHRH)

Gonadotropin releasing hormone


corticotrophin releasing factor


growth hormone releasing hormone

GHRIH (somatostatin)

growth hormone release inhibiting hormone


prolactin releasing factor


Prolactin inhibiting factor






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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • B. L. Brown
    • 1
  1. 1.Department of Nuclear Medicine, The Middlesex Hospital Medical SchoolThorn Institute of Clinical ScienceLondonUK

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