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Studies on the Permissive Effect of the Thyroid on fat Cells

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Eukaryotic Cell Function and Growth

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Abstract

Fat cells from normal rats respond to a variety of hormones (including the catecholamines, glucagon and ACTH with an increase in the rate of lipolysis. Most of the available evidence is compatible with the hypothesis that this effect is mediated by cyclic AMP (1). Fat cells from hypothyroid rats are unresponsive to these hormones, which is to say that thyroid hormones exert a permissive effect for lipolysis. We have recently carried out a series of studies designed to elucidate the mechanism of this effect.

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Abbreviations

ACTH:

Adrenocorticotrophic hormone

PDE:

phosphodiesterase

PTU:

propylthiouracil

MIX:

1-methyl-3-isobutylxanthine (SC2964)

T3 :

triiodothyronine

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Author information

Authors and Affiliations

  1. The University of Texas Medical School, Houston, Texas, 77025, USA

    G. A. Robison, R. G. Van Inwegen, W. J. Thompson & J. E. Stouffer

  2. Baylor College of Medicine, Houston, Texas, 77025, USA

    J. E. Stouffer

Authors
  1. G. A. Robison
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  2. R. G. Van Inwegen
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  3. W. J. Thompson
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  4. J. E. Stouffer
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Editor information

Editors and Affiliations

  1. Institute of Interdisciplinary Research, University of Brussels Medical Schools, Brussels, Belgium

    Jacques E. Dumont

  2. Institute of Nuclear Medicine, Thorn Institute of Clinical Sciences, The Middlesex Hospital Medical School, London, UK

    Barry L. Brown  & Nicholas J. Marshall  & 

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© 1976 Plenum Press, New York

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Robison, G.A., Van Inwegen, R.G., Thompson, W.J., Stouffer, J.E. (1976). Studies on the Permissive Effect of the Thyroid on fat Cells. In: Dumont, J.E., Brown, B.L., Marshall, N.J. (eds) Eukaryotic Cell Function and Growth. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4322-6_28

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  • DOI: https://doi.org/10.1007/978-1-4613-4322-6_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4324-0

  • Online ISBN: 978-1-4613-4322-6

  • eBook Packages: Springer Book Archive

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