Determination of Cyclic GMP in Biological Material

  • Karl Heinrich Jakobs
  • Eycke Böhme
  • Günter Schultz


Guanosine 3′,5′-monophosphate (cGMP) has been detected in most animal (11) and plant (12) tissues and in bacteria (1). Its concentration generally varies between 10-8 and 10-7 mol/kg wet weight, although in some cases it can be as high as 10-6 mol/kg (11). This is very low compared to the concentrations of related nucleotides and of cAMP.


Tissue Extract Cyclic Nucleotide Cyclic Monophosphate Cyclic Nucleotide Phosphodiesterase Competitive Binding Assay 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Karl Heinrich Jakobs
    • 1
  • Eycke Böhme
    • 1
  • Günter Schultz
    • 1
  1. 1.Department of PharmacologyUniversity of HeidelbergHeidelbergGermany

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