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The Localization of Glutamate Decarboxylase, Choline Acetyltransferase, and Aromatic Amino Acid Decarboxylase in Mammalian and Invertebrate Nervous Tissue

  • Chapter
Metabolic Compartmentation and Neurotransmission

Abstract

A chemical transmitter is specifically released from the presynaptic element during stimulation. The transmitter must therefore be supplied to the presynaptic terminal in order to maintain the release at a sufficient rate. This can be achieved either by synthesizing the substance in the presynaptic compartment, by an efficient and rapid uptake of the transmitter into the presynaptic terminal, or both. When the synthesis of a chemical transmitter depends on a specific enzyme, then the localization of the enzyme is probably a better marker for that nerve terminal than the transmitter itself, which may be redistributed by uptake or diffusion into neighboring structures (Fonnum, 1912a).

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  1. Division of Toxicology, Norwegian Defence Research Establishment, Kjeller, Norway

    F. Fonnum

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  1. Mt. Sinai School of Medicine, New York, New York, USA

    Soll Berl

  2. Fordham University, Bronx, New York, USA

    D. D. Clarke

  3. Neurosciences Research Program, Boston, Massachusetts, USA

    Diana Schneider

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Fonnum, F. (1975). The Localization of Glutamate Decarboxylase, Choline Acetyltransferase, and Aromatic Amino Acid Decarboxylase in Mammalian and Invertebrate Nervous Tissue. In: Berl, S., Clarke, D.D., Schneider, D. (eds) Metabolic Compartmentation and Neurotransmission. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4319-6_6

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  • DOI: https://doi.org/10.1007/978-1-4613-4319-6_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4321-9

  • Online ISBN: 978-1-4613-4319-6

  • eBook Packages: Springer Book Archive

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