Uptake and Localization of Transmitter Amino Acids in the Nervous System

  • L. L. Iversen
  • Fabienne Dick
  • J. S. Kelly
  • F. Schon

Abstract

This chapter will review the present status of research in our laboratory on the use of autoradiographic techniques for identifying and mapping the cellular distribution in mammalian CNS of neurons that use amino acid transmitters. This approach is based on the hypothesis that such neurons possess unique high-affinity uptake sites for the amino acids that they employ as transmitters, so that a particular category of neuron may be selectively labeled by exposure (of nervous tissue) to a low concentration of the radioactively labeled transmitter. A further assumption is that such high-affinity uptake sites for amino acid transmitters are localized exclusively in the neurons that store and release such substances. How far these basic assumptions are valid will be illustrated mainly by reference to the amino acid GABA, whose uptake and localization has so far been most extensively investigated.

Keywords

Dopamine Glycine Retina Pyruvate Histamine 

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • L. L. Iversen
    • 1
  • Fabienne Dick
    • 1
  • J. S. Kelly
    • 1
  • F. Schon
    • 1
  1. 1.M. R. C. Neurochemical Pharmacology Unit Department of PharmacologyUniversity of CambridgeCambridgeEngland

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