Abstract
Cholinergic nerve endings are able to take up choline, part of which is converted into acetylcholine (ACh) soon after uptake (Browning and Schulman, 1968; Chakrin and Shideman, 1968), and this newly formed ACh has a greater chance of being released from nerve endings than previously stored ACh. This has been demonstrated in the perfused superior cervical ganglion of the cat (Collier, 1969), the isolated phrenic nerve diaphragm preparation of the rat (Potter, 1970), rat brain cortex slices (Molenaar et al., 1971, 1973a), the guinea pig brain in vivo (Chakrin et al., 1972), and the isolated electroplax of Torpedo (Dunant et al., 1972). Preferential release of newly synthesized transmitter is not confined to cholinergic neurons, but also takes place in dopaminergic (Besson et al., 1969) and noradrenergic systems (Kopin et al., 1968).
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© 1975 Plenum Press, New York
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Molenaar, P.C., Polak, R.L. (1975). Preferential Release of Newly Synthesized Acetylcholine by Cortex Slices from Rat Brain. In: Berl, S., Clarke, D.D., Schneider, D. (eds) Metabolic Compartmentation and Neurotransmission. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4319-6_39
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DOI: https://doi.org/10.1007/978-1-4613-4319-6_39
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