Abstract
Clarification of the relationship between brain serotonin metabolism and cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) levels is of crucial importance in advancing our understanding of the physiology of these compounds and in providing information about possible metabolic changes in the brains of patients with neurologic and psychiatric disorders. There are two main views regarding this relationship: (i) that most 5-HIAA is excreted directly from the brain into the bloodstream, or (ii) that 5-HIAA first enters the CSF and is then excreted into the blood by bulk flow and via the active transport system of the choroid plexus. Resolution of this problem is of importance to biomedical research because the study of the concentration of 5-HIAA in the CSF is one of the few potential strategies available for gaining information about the metabolism of serotonin (5-HT) in the human brain.
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© 1975 Plenum Press, New York
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Burns, D., Brunswick, D., London, J., Mendels, J. (1975). The Kinetics of 5-Hydroxyindoleacetic Acid Excretion from Rat Brain and CSF: Preliminary Studies and Multicompartment Analysis. In: Berl, S., Clarke, D.D., Schneider, D. (eds) Metabolic Compartmentation and Neurotransmission. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4319-6_35
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DOI: https://doi.org/10.1007/978-1-4613-4319-6_35
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