Abstract
As was demonstrated in many of the chapters in this volume, the compartmentation of amino acid metabolism in brain is directly correlated with the fact that amino acids such as glutamate must function at several levels, e.g., in protein metabolism, in maintaining energy requirements, as well as perhaps having a direct role in nerve transmission as neurotransmitters or neuromodulator substances. Indeed, evidence continues to accumulate concerning the role of amino acids as putative transmitters in the CNS (see other chapters in this volume). Roberts and Matthysse (1970), among others, have postulated that the physiological interplay of the excitatory and inhibitory systems that interact to maintain homeostasis raises the possibility that biochemical cross-regulation may exist between synapses with different neurotransmitter systems. Watkins (1973) has also reviewed the possibility of metabolic regulation in transmitter processes. In addition, transmitter release, uptake, and metabolism require energy. Since glutamate and its related metabolites are directly associated with the tricarboxylic acid cycle, it might be expected that the metabolic turnover of these amino acids would also reflect the energy needs of the brain.
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Nicklas, W.J., Berl, S., Clarke, D.D. (1975). Relationship between Amino Acid and Catecholamine Metabolism in Brain. In: Berl, S., Clarke, D.D., Schneider, D. (eds) Metabolic Compartmentation and Neurotransmission. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4319-6_30
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DOI: https://doi.org/10.1007/978-1-4613-4319-6_30
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