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IgE-Myelomas in Rats

  • Chapter
Molecular and Biological Aspects of the Acute Allergic Reaction

Abstract

Monoclonal immunoglobulins synthesized by myelomas (plasmo cytomas, immunocytomas) are a valuable asset in the study of structure, synthesis and physiological properties of the immuno globulins. This type of tumour is wellknown in man. In animals, it has been described in mice (Dunn, 1954), dogs (Groulade, Morel, Creyssel & Groulade, 1959), hamsters (Mohr & Dontenwill, 1964), horses (Dorrington & Rockey, 1968) and cats (Kehoe, Hurvitz & Capra, 1972). But the very low spontaneous incidence of this type of tumour in animals has not provided a great variety of different monoclonal immunoglobulins. Moreover, in most of these species, tumourtransplantation is not possible for lack of inbred strains and therefore, the quantity of myeloma proteins available is generally restricted.

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Author information

Authors and Affiliations

  1. Experimental Immunology Unit, Faculty of Medicine, University of Louvain, Belgium

    Hervé Bazin

  2. Clos Chapelle-aux-champs, 30-1200, Brussels, Belgium

    Andrée Beckers

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  1. Hervé Bazin
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  2. Andrée Beckers
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Editors and Affiliations

  1. University Hospital, Uppsala, Sweden

    S. G. O. Johansson

  2. Karolinska Institute, Stockholm, Sweden

    Kjell Strandberg  & Börje Uvnäs  & 

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© 1976 Plenum Press, New York

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Bazin, H., Beckers, A. (1976). IgE-Myelomas in Rats. In: Johansson, S.G.O., Strandberg, K., Uvnäs, B. (eds) Molecular and Biological Aspects of the Acute Allergic Reaction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4304-2_6

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  • DOI: https://doi.org/10.1007/978-1-4613-4304-2_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4306-6

  • Online ISBN: 978-1-4613-4304-2

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