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Specificity and Modulation of the Eosinophil Polymorphonuclear Leukocyte Response to the Eosinophil Chemotactic Factor of Anaphylaxis (ECF-A)

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Molecular and Biological Aspects of the Acute Allergic Reaction

Abstract

After their generation from myeloid precursors in bone marrow, eosinophil polymorphonuclear (PMN) leukocytes circulate for a brief period in peripheral blood and then emigrate to tissue pools localized predominantly in the lungs, skin, intestines and genitourinary tract (Hudson, 1968; Spry, 1971; Zucker-Franklin, 1974). An increase in the level of eosinophils in peripheral blood and in involved tissues is a prominent feature of systemic immediate hypersensitivity reactions (Campbell et al, 1935). The selective influx of eosinophils to the focus of an immediate hypersensitivity reaction is governed by the tissue levels of diverse eosinophil chemotactic factors, by the biodegradation or inhibition of the chemotactic factors, and by reversible and irreversible alterations in the chemotactic responsiveness of the target cells (Goetzl et al, 1975). The net effect of this series of interactions is the positioning of a critical number of eosinophils at the site of an immediate hypersensitivity reaction so that they may exercise their specific regulatory role (Goetzl et al, 1975).

supported by grants AI-07722 and AI-10356 from the National Institutes of Health.

Investigator, Howard Hughes Medical Institute.

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Authors and Affiliations

  1. Departments of Medicine, Harvard Medical School, Robert B. Brigham Hospital, 02120, Boston, Mass., USA

    Edward J. Goetzl & K. Frank Austen

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  1. Edward J. Goetzl
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  2. K. Frank Austen
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Editors and Affiliations

  1. University Hospital, Uppsala, Sweden

    S. G. O. Johansson

  2. Karolinska Institute, Stockholm, Sweden

    Kjell Strandberg  & Börje Uvnäs  & 

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© 1976 Plenum Press, New York

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Goetzl, E.J., Austen, K.F. (1976). Specificity and Modulation of the Eosinophil Polymorphonuclear Leukocyte Response to the Eosinophil Chemotactic Factor of Anaphylaxis (ECF-A). In: Johansson, S.G.O., Strandberg, K., Uvnäs, B. (eds) Molecular and Biological Aspects of the Acute Allergic Reaction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4304-2_21

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  • DOI: https://doi.org/10.1007/978-1-4613-4304-2_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4306-6

  • Online ISBN: 978-1-4613-4304-2

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