The Hageman Factor System: Mechanism of Contact Activation

  • John H. Griffin
  • Susan D. Revak
  • Charles G. Cochrane


The role of the components of the Hageman factor system in the pathogenesis of inflammation is poorly understood. In order to examine the potential participation of the system in inflammation, abundant work has been performed in the past several years to delineate the component proteins and examine their mechanisms of interaction. In this paper, we wish to review the state of knowledge of the system, including the latest information available regarding the activation of Hageman factor, and to summarize the inflammatory properties attributed to its members.


Factor System Contact Activation High Molecular Weight Kininogen Deficient Plasma Hageman Factor 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • John H. Griffin
    • 1
  • Susan D. Revak
    • 1
  • Charles G. Cochrane
    • 1
  1. 1.Department of ImmunopathologyScripps Clinic and Research FoundationLa JollaUSA

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