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Mast Cell-Derived Mediators: Structural and Functional Diversity and Regulation of Expression

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Book cover Molecular and Biological Aspects of the Acute Allergic Reaction

Abstract

Since the mast cell is the only cell type possessing a specific recognition unit, IgE, for a foreign substance and located in the tissues in general rather than in a circulation, hematogenous or lymphatic, the physiologic role of this cell in host defense may be to recruit proteins and cells from the circulation in the absence of appreciable local tissue injury. After immunologic activation the mast cell elaborates mediators that alter the microenvironment so as to achieve the influx of plasma proteins, including immunoglobulins and complement components, and the ingress of phagocytic tissue and peripheral blood cells to the locus of the reaction.

Supported by grants AI-07722 and AI-10356 from the National Institutes of Health.

Postdoctoral Fellow of The Arthritis Foundation.

Investigator, Howard Hughes Medical Institute.

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References

  • Allen, E., and Roy, A.B. 1968. The sulfatase of ox liver. XI. The isoelectric focusing of a purified preparation of sulfatase B. Biochim. Biophys. Acta 168:243.

    PubMed  CAS  Google Scholar 

  • Baker, A.R., Bloch, K.J., and Austen, K.F. 1964. In vitro passive sensitization of chopped guinea pig lung by guinea pig 7S antibodies. J. Immunol, 93;525.

    PubMed  CAS  Google Scholar 

  • Baum, H., Dodgson, K.S., and Spencer, B. 1959. The assay of arylsulfatase A and B in human urine. Clin. Chim. Acta 4:453.

    Article  PubMed  CAS  Google Scholar 

  • Benveniste, J. 1974. Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils. Nature 249:581.

    Article  PubMed  CAS  Google Scholar 

  • Benveniste, J., Henson, P.M., and Cochrane, C.G. 1972. Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor. J. Exp. Med. 136:1356.

    Article  PubMed  CAS  Google Scholar 

  • Benveniste, J., Kamoun, P., and Polonsky, J. 1975. Aggregation of human platelets by purified platelet activating factor from human and rabbit basophils. Fed. Proc. 34:985 (abstract).

    Google Scholar 

  • Bleszynski, W., Leznicki, A., and Lewosz, J. 1969. Kinetic properties of three soluble arylsulfatases from ox brain, homogeneous in polyacrylamide gel electrophoresis. Enzymologica 37:314.

    CAS  Google Scholar 

  • Bleszynski, W.S., and Roy, A.B. 1973. Some properties of sulfatase B of ox brain. Biochim. Biophys. Acta 317:164.

    PubMed  CAS  Google Scholar 

  • Black, J.W., Duncan, W.A.M., Durant, C.J., Cannellin, C.R., and Parson, E.M. 1972. Definition and antagonism of histamine H2-receptors; Nature 236:385.

    Article  PubMed  CAS  Google Scholar 

  • Bloom, G., and Ringertz, N.R. 1961. Acid polysaccharides of peritoneal mast cells of the rat and mouse. Arkiv för Kemi 16:51.

    CAS  Google Scholar 

  • Bogart, D.B., and Stechschulte, D.J. 1974. Release of platelet activating factor from human lung. Clin. Res. 22:652 (abstract).

    Google Scholar 

  • Boyden, S. 1962. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes. J. Exp. Med. 115:453.

    Article  PubMed  CAS  Google Scholar 

  • Böyum, A. 1968. Isolation of leucocytes from human blood, further observations. Scand. J. Clin. Lab. Invest. 21: (Suppl. 97):31.

    Google Scholar 

  • Breslow, J.C., and Sloan, H.F. 1972. Purification of arylsulfatase A from human urine. Biockem. Biophys. Res. Commu. 46:919.

    Article  CAS  Google Scholar 

  • Brocklehurst, W.E. 1960. The release of histamine and formation of a slow-reacting substance (SRS-A) during anaphylactic shock. J. Physiol. 151:416.

    PubMed  CAS  Google Scholar 

  • Brocklehurst, W.E. 1962. Slow reacting substance and related compounds. Progr. Alierg. 6:539.

    CAS  Google Scholar 

  • Citron, K.M., Frankland, A.W., and Sinclair, J.D. 1958. Inhalation tests of broncho-hypersensitivity in pollen asthma. Thorax 13:229.

    Article  PubMed  CAS  Google Scholar 

  • Clark, R.A., Gallin, J.I., and Kaplan, A.P. 1975. The selective eosinophil chemotactic activity of histamine. J. Exp Med. 142:1462.

    Article  PubMed  CAS  Google Scholar 

  • Damus, P.S., Hicks, M., and Rosenberg, R.D. 1973. Anticoagulant action of heparin. Nature 246:355.

    Article  PubMed  CAS  Google Scholar 

  • DiAugustine, R.P. 1974. Lung concentric laminar organelle: Hydrolase activity and compositional analysis. 249:584.

    CAS  Google Scholar 

  • Dodgson, K.S., and Spencer, B. 1957. Assay of sulfatases. Meth. Biochem. Analysis 4:211.

    Article  CAS  Google Scholar 

  • Dodgson, K.S., Spencer, B., and Thomas, J. 1955. Studies on sulfatases. 9. The arylsulfatase of mammalian liver. Bio chem. J. 59:29.

    CAS  Google Scholar 

  • Dodgson, K.S., Spencer, B., and Wynn, C.H. 1956. The arylsulfatases of human tissues. Biochem. J. 62:500.

    PubMed  CAS  Google Scholar 

  • Dolovich, J., Hargreave, F.E., Chalmers, R., Shier, K.J., Gauldie, J., and Bienenstock, J. 1973. Late cutaneous allergic responses in isolated IgE-dependent reactions. J. Allergy Clin. Immunol. 49:43.

    Article  Google Scholar 

  • Drazen, J.M., and Austen, K.F. 1974. Effects of intravenous administration of slow reacting substance of anaphylaxis, histamine, bradykinin, and prostaglandin F2αon pulmonary mechanics in the guinea pig. J. Clin. Invest. 53:1679.

    Article  PubMed  CAS  Google Scholar 

  • Drazen, J.M., and Austen, K.F. 1975. Atropine modification of the pulmonary effects of chemical mediators in the guinea pig. J. Appl. Physiol. 38:834.

    PubMed  CAS  Google Scholar 

  • Feltkamp-Vroon, T.M., Stallman, P.J., Analberse, R.C., and Reerink-Bronkers, E.E. 1975. Immunofluorescence studies on renal tissue, tonsils, adenoids, nasal polyps, and skin of atopic and non-atopic patients with special reference to I. Clin. Immunol. Immunopathol. 4:392.

    Article  Google Scholar 

  • Fillion, G.M.B., Storach, S.A., and Uvnäs, B. 1970. The release of histamine, heparin and granule protein from rat mast cells treated with compound 48/80 in vitro. Acta Physiol. Scand. 78:547.

    Article  PubMed  CAS  Google Scholar 

  • Fraenkel-Conrat, H., and Tsung, C.M. 1967. Hydrazinolysis. In: METHODS IN ENZYMOLOGY, Vol. XI, p. 151, (C.H.W. Hirs, ed.) Academic Press, New York.

    Google Scholar 

  • Goetzl, E.J., and Austen, K.F. 1972. A neutrophil-immobilizing factor derived from human leukocytes. I. Generation and partial characterization. J. Exp. Med. 136:1564.

    Article  PubMed  CAS  Google Scholar 

  • Goetzl, E.J., and Austen, K.F. 1975. Purification and synthesis of eosinophilotactic tetrapeptides of human lung tissue: Identification as eosinophil chemotactic factor of anaphylaxis. Proc. Natl. Acad. Sci. 72:4123.

    Article  PubMed  CAS  Google Scholar 

  • Goetzl, E.J., Rubin, R.H., Monough, J., Tashjian, A.H., and Austen, K.F. 1976. Production of eosinophilotactic peptides by bronchogenic carcinoma in situ and in vitro. J. Clin. Invest (abstract), in press.

    Google Scholar 

  • Grant, J.A., and Lichtenstein, L.M. 1974. Release of slow reacting substance of anaphylaxis from human leukocytes. J. Immunol. 112:897.

    PubMed  CAS  Google Scholar 

  • Gray, W.R. 1967. Sequential degradation plus dansylation. In: METHODS IN ENZYMOLOGY, Vol. XI, p. 469, (C.H.W. Hirs, ed.) Academic Press, New York.

    Google Scholar 

  • Gutte, B., and Merrifield, R.B. 1971. The synthesis of ribonuclease A. J. Biol. Chem. 246:1922.

    PubMed  CAS  Google Scholar 

  • Hargreave, F.E., and Pepys, J. 1972. Allergic respiratory reactions in bird fanciers provoked by allergen inhalation provocation tests. Relation to clinical features and allergic mechanism. J. Allergy Clin. Immunol. 50:157.

    Article  PubMed  CAS  Google Scholar 

  • Hargreave, F.E., Pepys, J., Longbottom, J.L., and Wraith, D.G. 1966. Bird breeder’s (fancier’s) lung. Lancet 1:44.

    Google Scholar 

  • Harinath, B.C., and Robins, E. 1971. Arylsulfatase in human brain. Separation, purification and certain properties of the two soluble arylsulfatases. J. Neurochem. 18:245.

    Article  PubMed  CAS  Google Scholar 

  • Hartley, B.S. 1970. Strategy and tactics in protein chemistry. Biochem. J. 119:805.

    PubMed  CAS  Google Scholar 

  • Highsmith, R.F., and Rosenberg, R.D. 1974. The inhibition of human plasmin by human antithrombin-heparin cofactor. J. Biol. Chem. 249:4335.

    PubMed  CAS  Google Scholar 

  • Hubscher, T. 1975. Role of the eosinophil in the allergic reactions. I. EDI - An eosinophil-derived inhibitor of histamine release. J. Immunol. 114:1379.

    PubMed  CAS  Google Scholar 

  • Jaques, L.B., Monkhouse, F.C., and Steward, M. 1949. A method for the determination of heparin in blood. J. Physiol. 109:41.

    PubMed  CAS  Google Scholar 

  • Jefry, A., and Roy, A.B. 1973. The sulfatase of ox liver. XVI. A comparison of the arylsulfatase and cerebroside sulfatase activities of arylsulfatase A. Biochim. Biophys. Acta 293:178.

    Google Scholar 

  • Kaliner, M., and Austen, K.F. 1973. A sequence of biochemical events in the antigen-induced release of chemical mediators from sensitized human lung tissue. J. Exp. Med. 138:1077.

    Article  PubMed  CAS  Google Scholar 

  • Kaliner, M., and Austen, K.F. 1974a. Hormonal control of the immunologic release of histamine and slow reacting substance of anaphylaxis from human lung. In: CYCLIC AMP, CELL GROWTH, AND THE IMMUNE RESPONSE, p. 163, (W. Braun, L.M. Lichtenstein, and C.W. Parker, eds.) Springer-Verlag, New York.

    Google Scholar 

  • Kaliner, M., and Austen, K.F. 1974b. Cyclic AMP, ATP, and reversed anaphylactic histamine release from rat mast cells. J. Immunol. 112:664.

    PubMed  CAS  Google Scholar 

  • Kaliner, M., Orange, R.P., and Austen, K.F. 1972. Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. IV. Enhancement by cholinergic and alpha adrenergic stimulation. J. Exp. Med. 136:556.

    Article  PubMed  CAS  Google Scholar 

  • Kaliner, M., Wasserman, S.I., and Austen, K.F. 1973. Immunologic release of chemical mediators from human nasal polyps. New Engl. J. Med. 289:277.

    Article  PubMed  CAS  Google Scholar 

  • Kater, L.A., Goetzl, E.J., and Austen, K.F. 1976. Isolation of human eosinophil phospholipase D. J. Clin. Invest., in press.

    Google Scholar 

  • Kay, A.B., and Austen, K.F. 1971. The IgE-mediated release of an eosinophil leukocyte chemotactic factor from human lung. J. Immunol. 107:899.

    PubMed  CAS  Google Scholar 

  • Kay, A.B., Stechschulte, D.J., and Austen, K.F. 1971. An eosinophil leukocyte cnemotactic factor of anaphylaxis. J. Exp. Med. 133:602.

    Article  PubMed  CAS  Google Scholar 

  • Kravis, T.C., and Henson, P.M. 1975. IgE-induced release of a platelet-activating factor from rabbit lung. J. Immunol. 115:1677.

    PubMed  CAS  Google Scholar 

  • Lewis, R.A., Wasserman, S.I., Goetzl, E.J., and Austen, K.F. 1974. Formation of SRS-A in human lung tissue and cells before release. J. Exp. Med. 140:1133.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, R.A., Goetzl, E.J., Wasserman, S.I., Valone, F.H., Rubin, R.H., and Austen, K.F. 1975. The release of four mediators of immediate hypersensitivity from human leukemic basophils. J. Immunol. 114:87.

    PubMed  CAS  Google Scholar 

  • Lichtenstein, L.M., and Gillespie, E. 1975. The effects of the H1 and H2 antihistamines on “allergic” histamine release and its inhibition by histamine. J. Pharmacol. Exp. Ther. 192:441.

    PubMed  CAS  Google Scholar 

  • Lloyd, A.G., Bloom, G.D., and Balazs, E.A. 1967a. Evidence for the covalent association of heparin and protein in mast-cell granules. Biochem. J. 103:76.

    Google Scholar 

  • Lloyd, A.G., Bloom, G.D., Balazs, E.A., and Haegermark, O.1967b. Combined biochemical and morphological ultrastructure studies on mast-cell granules. Biochem. J. 103:75.

    Google Scholar 

  • Matsuo, H., Fujimoto, Y., and Tatsuno, T. 1966. A novel method for the determination of C-terminal amino acid in polypeptides by selective tritium labelling. Biochem. Biophys. Res. Commun. 22:69.

    Article  PubMed  CAS  Google Scholar 

  • McCarthy, D.S., and Pepys, J. 1971. Allergic bronchopulmonary aspergillosis. Clinical Immunology: (2) Skin, nasal, and bronchial tests. Clin. Allergy 1:415.

    Article  PubMed  CAS  Google Scholar 

  • Mehl, E., and Jatzhewitz, H. 1968. Cerebroside 3-sulfate as a physiological substrate of arylsulfatase A. Biochim. Biophys. Acta 151:619.

    PubMed  CAS  Google Scholar 

  • Morse, H.C., III, Bloch, K.J., and Austen, K.F. 1968. Biologic properties of rat antibodies. II. Time-course of appearance of antibodies involved in antigen-induced release of slow reacting substance of anaphylaxis (SRS-Arat); association of this activity with rat IgGa. J. Immunol. 101:658.

    PubMed  CAS  Google Scholar 

  • Neuwelt, E., Stumpf, D., Austin, J., and Kohler, P. 1971. A monospecific antibody to human sulfatase A: Preparation, characterization and significance. Biochim. Biophys. Acta 236:333.

    PubMed  CAS  Google Scholar 

  • Nichol, L.W., and Roy, A.B. 1965. The sulfatase of ox liver. IX. The polymerization of sulfatase A. Biochemistry 4:386.

    Article  PubMed  CAS  Google Scholar 

  • Odegard, O.R., Lie, M., and Abildgaard, U. 1975. Heparin cofactor activity measured with an amidolytic method. Thrombosis Res. 6:287.

    Article  CAS  Google Scholar 

  • Orange, R.P. 1973. Immunopharmacological aspects of bronchial asthma. Clin. Allergy 3:(Supplement):521.

    Google Scholar 

  • Orange, R.P. 1974. The formation and release of slow reacting substance of anaphylaxis in human lung tissues. In: PROGRESS IN IMMUNOLOGY II, Vol. 4, p. 29 (L. Brent and J. Holborow, eds.) North Holland Publishing Co., Amsterdam.

    Google Scholar 

  • Orange, R.P., Stechschulte, D.J., and Austen, K.F. 1969. Cellular mechanisms involved in the release of slow reacting substance of anaphylaxis. Fed. Proc. 28:1710.

    PubMed  CAS  Google Scholar 

  • Orange, R.P., Stechschulte, D.J., and Austen, K.F. 1970. Immunochemical and biologic properties of rat IgE. II. Capacity to mediate the immunologic release of histamine and slow reacting substance of anaphylaxis (SRS-A). J. Immunol. 105:1087.

    PubMed  CAS  Google Scholar 

  • Orange, R.P., Austen, W.G., and Austen, K.F. 1971. Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. I. Modulation by agents influencing cellular levels of cyclic 3’,5’-adenosine monophosphate. J. Exp. Med. 134:136s.

    Google Scholar 

  • Orange, R.P., Murphy, R.C., Karnovsky, M.L., and Austen, K.F.1973. The physicochemical characteristics and purification of slow reacting substance of anaphylaxis. J. Immunol. 110:760.

    PubMed  CAS  Google Scholar 

  • Orange, R.P., Murphy, R.C., and Austen, K.F. 1974. Inactivation of slow reacting substance of anaphylaxis (SRS-A) by arylsulfatases. J. Immunol. 113:316.

    PubMed  CAS  Google Scholar 

  • Paterson, N.A.M., Wasserman, S.I., Said, J., Kater, L.A., and Austen, K.F. 1976. Mediator release from human lung cells distributed according to density. Fed. Proc. (abstract), in press.

    Google Scholar 

  • Patterson, R., and Suszko, I.M. 1971. Primate respiratory mast cells. Reactions with ascaris antigen and anti-heavy chain sera. J. Immunol. 106:1274.

    Google Scholar 

  • Patterson, R., Tomita, Y., Oh, S.H., Suszko, I.M., and Pruzansky, J.J. 1974. Respiratory mast cells and basophiloid cells. I. Evidence that they are secreted into the bronchial lumen, morphology, degranulation, and histamine rselease. Clin. Exp. Immunol. 16:223.

    Google Scholar 

  • Payne, W.J., Fitzgerald, J.W., and Dodgson, K.S. 1974. Methods for visualization of enzyme in polyacrylamide gels. Appl. Microbiol. 27:154.

    PubMed  CAS  Google Scholar 

  • Pepys, J., Turner-Warwick, M., Dawson, P.L., and Hinson, K.R.W. 1968. Arthus (type III) skin test reactions in man. Clinical and immunopathological features. In: ALLERGOLOGY, p. 221, (B. Rose, R. Richter, A. Sehon, and A.W. Frankland, eds.) Excerpta Medica Foundation, No. 162, Amsterdam.

    Google Scholar 

  • Rent, R., and Fiedel, B. 1975. Effect of heparin on Cl-esterase inhibitor (Cl-INH). Fed. Proc. 34:964 (abstract).

    Google Scholar 

  • Riley, J.F., and West, G.B. 1953. The presence of histamine in tissue mast cells. J. Physiol. 120:528, 1953.

    Google Scholar 

  • Rosenberg, R.D., and Damus, P.S. 1973. Purification and mechanism of action of human antithrombin-heparin cofactor. J. Biol. Chem. 248:6490.

    PubMed  CAS  Google Scholar 

  • Roy, A.B. 1957. Sulfatase of ox liver. I. Complex nature of the enzyme. Biochem. J. 53:12.

    Google Scholar 

  • Roy, A.B. 1970. The product inhibition of sulfatase B. Biochim. Biophys. Acta 198:365.

    Google Scholar 

  • Roy, A.B. 1971. The type II arylsulfatase of the red kangaroo. Biochim. Biophys. Acta. 227:129.

    PubMed  CAS  Google Scholar 

  • Schayer, R.W. 1959. Catabolism of physiological quantities of histamine in vivo. Physiol. Rev. 39:116.

    PubMed  CAS  Google Scholar 

  • Shapna, E., and Nadier, H.L. 1975. Purification and some properties of soluble human liver arylsulfatases. Arch. Biochem. Biophys. 170:179.

    Article  Google Scholar 

  • Siraganian, R.P., and Osier, A.G. 1971. Destruction of rabbit platelets in the allergic response of sensitized leukocytes. I. Evidence of basophil involvement. J. Immunol. 106:1252.

    PubMed  CAS  Google Scholar 

  • Spackman, D.H., Stein, W.H., and Moore, S. 1958. Automatic recording apparatus for use in the chromatography of amino acids. Anal. Chem. 30:1490.

    Article  Google Scholar 

  • Stevens, R.L., Fluharty, A.L., Skokut, M.H., and Kihara, H. 1975. Purification and properties of arylsulfatase A from human urine. J. Biol. Chem. 250:2495.

    PubMed  CAS  Google Scholar 

  • Stewart, J.M., and Young, J.P. 1969. SOLID PHASE PEPTIDE SYNTHESIS, W.H. Freeman and Co., San Francisco.

    Google Scholar 

  • Standberg, K., and Hedqvist, P. 1975. Airway effects of slow reacting substance, prostaglandin F2αand histamine in the guinea pig. Acta Physiol. Scand. 9:105.

    Article  Google Scholar 

  • Tauber, A.I., Kaliner, M., Stecnschulte, D.J., and Austen, K.F. 1973. Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. V. Effects of prostaglandins on release of histamine. J. Immunol. 111:27.

    PubMed  CAS  Google Scholar 

  • Taylor, G., and Shivalkar, P.R. “Arthus-type” reactivity in the nasal airways and skin in pollen sensitive subjects. Clin. Allergy 1:407.

    Google Scholar 

  • Ward, P.A., and Becker, E.L. 1968. The deactivation of rabbit neutrophils by chemotactic factor and the nature of the activatable esterase. J. Exp. Med. 127:693, 1968.

    Google Scholar 

  • Wasserman, S.I., and Austen, K.F. 1976. Arylsulfatase B of human lung: Isolation, characterization and interaction with slow reacting substance of anaphylaxis. J. Clin. Invest., in press.

    Google Scholar 

  • Wasserman, S.I., Goetzl, E.J., and Austen, K.F. 1974a. Preformed eosinophil chemotactic factor of anaphylaxis (ECF-A). J. Immunol. 112:351.

    PubMed  CAS  Google Scholar 

  • Wasserman, S.I., Goetzl, E.J., Ellman, L., and Austen, K.F. 1974b. Tumor associated eosinophilotactic factor. New Engl. J. Med. 290:420.

    CAS  Google Scholar 

  • Wasserman, S.I., Goetzl, E.J., and Austen, K.F. 1975a. Inactivation of slow reacting substance of anaphylaxis by human eosinophil arylsulfatase. J. Immunol. 114:645.

    PubMed  CAS  Google Scholar 

  • Wasserman, S.I., Whitmer, D., Goetzl, E.J., and Austen, K.F. 1975b. Chemotactic deactivation of human eosinophils by eosinophil chemotactic factor of anaphylaxis. Proc. Soc. Exp. Biol. Med. 148:301.

    PubMed  CAS  Google Scholar 

  • Wasserman, S.I., Goetzl, E.J., and Austen, K.F. 1975c. Inactivation of human SRS-A by intact human eosinophils and by eosinophil arylsulfatase. J. Allergy Clin. Immunol.55:72 (abstract).

    Google Scholar 

  • Wasserman, S.I., Boswell, R.N., Drazen, J.M., Goetzl, E.J., and Austen, K.F. 1976a. Functional specificity of the human lung acidic tetrapeptides constituting eosinophil chemotactic factor of anaphylaxis (ECF-A). J. Allergy Clin. Immunol, (abstract), in press.

    Google Scholar 

  • Wasserman, S.I., Soter, N.A., Center, D.M., and Austen, K.F. 1976b. Cold urticaria: The appearance in the circulation of a neutrophil chemotactic principle during cold challenge. Clin. Res. (abstract), in press.

    Google Scholar 

  • Woods, K.R., and Wang, K.T. 1967. Separation of dansyl-amino acids by polyamide layer chromatography. Biochim. Biophys. Acta 133:369.

    PubMed  CAS  Google Scholar 

  • Yin, E.T., Wessler, S., and Stoll, P.J. 1971. Identity of plasma-activated factor X inhibitor with antithrombin III and heparin cofactor. J. Biol. Chem. 246:3712.

    PubMed  CAS  Google Scholar 

  • Yurt, R.W., Leid, R.W., Silbert, J.E., Spragg, J., and Austen, K.F. 1976. Immunologic release of heparin from purified rat peritoneal mast cells. Fed. Proc. (abstract), in press.

    Google Scholar 

  • Zeiger, R.S., Yurdin, D.L., and Colten, H.R. 1976. Histamine metabolism: II. Cellular and subcellular localization of the catabolic enzymes, histaminase and histamine methyl transferase in human leukocytes. J. Allergy Clin. Immunol., in press.

    Google Scholar 

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Authors and Affiliations

  1. Departments of Medicine, Harvard Medical School, The Robert B. Brigham Hospital, 02120, Boston, Mass., USA

    K. Frank Austen, Stephen I. Wasserman & Edward J. Goetzl

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  1. K. Frank Austen
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  2. Stephen I. Wasserman
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  1. University Hospital, Uppsala, Sweden

    S. G. O. Johansson

  2. Karolinska Institute, Stockholm, Sweden

    Kjell Strandberg  & Börje Uvnäs  & 

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Austen, K.F., Wasserman, S.I., Goetzl, E.J. (1976). Mast Cell-Derived Mediators: Structural and Functional Diversity and Regulation of Expression. In: Johansson, S.G.O., Strandberg, K., Uvnäs, B. (eds) Molecular and Biological Aspects of the Acute Allergic Reaction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4304-2_15

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