Discussion Remark: Protein Kinases in Rat Mast Cells

  • B. B. Fredholm
  • B. Uvnäs

Abstract

Most if not all the known actions of cyclic nucleotides are mediated over protein kinases (1). In view of the recent data implicating cyclic AMP and cyclic GMP as modulators or even mediators of histamine release frcm mast cells (2) it was of interest to examine the mast cell protein kinases. The following is a brief report of our preliminary findings.

Keywords

EDTA Heparin Adenosine Histamine Mast 

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References

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    Langan, T.A.: Protein kinases and protein kinase substrates. Adv. Cyclic Nucleotide Res. 3: 99–153, 1973.PubMedGoogle Scholar
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    Parker, C.W., T.J. Sullivan and H.J. Wsdner: Cyclic AMP and the inmunic response. Adv. Cyclic Nucleotides Res. 4: 1–79, 1974.Google Scholar
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    Walsh, D.A., C.D. Ashby, C. Gonzales, D. Calkius, E.H. Fischer and E.G. Krebs: Purification and characterization of a protein inhibitor of adenosine 3’,5’-monophosphate-dependent protein kinases. J. Biol. Chem. 246: 1977–1985, 1971.PubMedGoogle Scholar
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    Kuo, J.F.: Divergent actions of protein kinase modulator in regulating mammalian cyclic GMP-dependent and cyclic AMP-dependent protein kinases. Metabolism. 24: 321–329, 1975.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • B. B. Fredholm
    • 1
  • B. Uvnäs
    • 1
  1. 1.Department of PharmacologyKarolinska institutetStockholm 60Sweden

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