The Complexation of Calcium Ion by Diphosphonates

  • W. F. Neuman


The complexation of calcium ion (Ca++) by monophosphonates (MP)* and diphosphonates (DP)* has been studied under conditions of physiological pH, temperature and ionic strength by the method of Schubert (1). In this procedure, the competition between the anionic ligand and a cation exchange resin for Ca++ is determined. Thus, with a fixed amount of Ca++, Ca45 and Dowex 50 WX4 resin 5 to 10 increments of DP were added to compete increasingly with the resin for Ca++.


Cation Exchange Resin Amino Derivative Anionic Ligand Proton Dissociation Satisfactory Linear 
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  1. 1.
    Schubert, J., J.Physiol.Chem. 56: 113–117 (1952).CrossRefGoogle Scholar
  2. 2.
    Gosselin, R.E. and Coghlan, E.R., Arch.Biochem.Biophys. 45: 301–311 (1953).PubMedCrossRefGoogle Scholar
  3. 3.
    Di Stefano, V. and Neuman, W.F., J.Biol.Chem. 200: 759–763 (1953).Google Scholar
  4. 4.
    Curry, J.D., Nicholson, D.A. and Quimby, O.T. “Oligophosphonates” in Topics in Phosphorus Chemistry (ed. by E.J. Griffith and M. Grayson) Vol. VII, pp. 37–102, John Wiley and Sons Inc., New York, N.Y., 1972.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • W. F. Neuman
    • 1
  1. 1.Department of PathophysiologyUniversity of BerneBerneSwitzerland

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