Nucleation Place for Urinary Calculi

Abstract

Numerous inquiries have dealt with the localization of urinary calculi and the calcification in the kidney. As localization were assigned: the lumen (Posey 1942), the epithelium of the renal tubule (Stout 1955), the interstitial tissue (Vermooten 1942), the surrounding of the vessels (Pyrah 1955), the papilla (Randell 1937) and the lymphatics of the kidney (Carr 1954). Examinations of Shigamatsou 1957 for the first time showed a disturbance of the permeability of the glomerula which opens a passage to ultra-finest colloid-particles. These colloidparticles are to be burdened with stoneforming substances in the region of the tubule and by that way they will gain their active form as starting-point of crystal formation. Malek and Boyce discovered in 1973 during biopsies of kidneys calcifications in the proximale and distale tubules of the kidney, where as they did not observe any calcifications in the glomerulum. Examinations of Anderson showed in 1968 calcifications of degenerated epithelium-cells of the tubule in the kidney. A primary localization of urinary calculi in the glomerulum and the Bowman’s capsule was until that time neither shown nor discussed.