Altered Excretion of 5-Hydroxyindoleacetic Acid and Glycine in Patients with the Lesch-Nyhan Disease

  • L. Sweetman
  • M. Borden
  • S. Kulovich
  • I. Kaufman
  • W. L. Nyhan
Part of the Advances in Experimental Medicine and Biology book series

Abstract

Mizuno and Yugari (1,2) reported that 5-hydroxytryptophan (5-HTP) given orally at 1–8 mg/kg/day was effective in preventing self-mutilation in four patients with the Lesch-Nyhan syndrome. The proposed mechanism of action was through alteration of seretonin (5-hydroxytryptamine, 5-HT) levels in the brain.

Keywords

Creatinine Glycine Electrophoresis Levodopa Purine 

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References

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • L. Sweetman
    • 1
  • M. Borden
    • 1
  • S. Kulovich
    • 1
  • I. Kaufman
    • 1
  • W. L. Nyhan
    • 1
  1. 1.Department of PediatricsUniversity of California, San DiegoLa JollaUSA

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