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Altered Excretion of 5-Hydroxyindoleacetic Acid and Glycine in Patients with the Lesch-Nyhan Disease

  • L. Sweetman
  • M. Borden
  • S. Kulovich
  • I. Kaufman
  • W. L. Nyhan
Part of the Advances in Experimental Medicine and Biology book series

Abstract

Mizuno and Yugari (1,2) reported that 5-hydroxytryptophan (5-HTP) given orally at 1–8 mg/kg/day was effective in preventing self-mutilation in four patients with the Lesch-Nyhan syndrome. The proposed mechanism of action was through alteration of seretonin (5-hydroxytryptamine, 5-HT) levels in the brain.

Keywords

Public Health Service Grant Peripheral Metabolism Glycine Cleavage System Urinary Amino Acid Plasma Glycine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Mizuno, T., and Yugari, Y.: Lancet p.761 (1974).Google Scholar
  2. 2.
    Mizuno, T., and Yugari, Y.: Neuropädiatric 6; 13–23 (1975).CrossRefGoogle Scholar
  3. 3.
    Sims, K.L.: In Adv. Biochem. Psychopharm. “Serotonin-New Vistas”, (E. Costa, G.L. Gessa and M. Sandler, Eds.) 11; 43–50, Raven Press, New York (1974).Google Scholar
  4. 4.
    Neff, N.H. et al.: In Adv. Biochem. Psychopharm. “Serotonin-New Vistas”, (E. Costa, G.L. Gessa and M. Sandler, Eds.) 11; 51–58, Raven Press, New York (1974).Google Scholar
  5. 5.
    Annotated Bibliography, MK-486 and Levodopa, Merck, Sharp and Dohme (1974).Google Scholar
  6. 6.
    Modigh, K.:In Adv. Biochem. Psychopharm. “Serotonin-New Vistas”, (E. Costa, G.L. Gessa and M. Sandler, Eds.) 10; 213–217, Raven Press, New York (1974).Google Scholar
  7. 7.
    Goldenberg, H.; Clin. Chem. 19; 38–44 (1973).PubMedGoogle Scholar
  8. 8.
    Kikuchi, G.; Mole. Cell. Biol. 1; 169–187 (1973).Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • L. Sweetman
    • 1
  • M. Borden
    • 1
  • S. Kulovich
    • 1
  • I. Kaufman
    • 1
  • W. L. Nyhan
    • 1
  1. 1.Department of PediatricsUniversity of California, San DiegoLa JollaUSA

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