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Turnover and Aortic Uptake of Very Low Density Lipoproteins (VLDL) from Hypercholesteremic Rabbits: Effect of Metformin

  • Cesare R. Sirtori
  • L. Innocenti
  • P. G. Grigolato
  • J. Rodriguez
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 82)

Abstract

Turnover of 125I-labelled very low density lipoproteins (VLDL) from hypercholesteremic (HC) rabbits, is markedly slower than that of VLDL from control rabbits. T ½ of the two lipoproteins, in the log-normal phase, is, respectively, of 22 hours, and of 16 hrs (1). Conversion of VLDL into low density lipoproteins (LDL), and high density lipoproteins (HDL) is very rapid and almost complete in the case of normal VLDL, while HC-VLDL is very slowly converted, and, up to 48 hrs after the injection, over 60% of the radioactivity remains in the VLDL fraction. These findings, i.e. a prolonged log-normal phase, and an inefficient conversion to lipoproteins of the higher density, can be demonstrated also when labelled VLDL from HC rabbits are injected into normal recipients.

Keywords

Cholesterol Ester High Density Lipoprotein Control Rabbit Group Choles Normal Recipient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Rodriguez J., Ghiselli G.C., Catapano A. and Sirtori C.R., Atherosclerosis, 1975, in pressGoogle Scholar
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    Rodriguez J., Ghiselli G.C., Torreggiani D. and Sirtori C.R., Atherosclerosis, 1975, in pressGoogle Scholar
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    Agid R., Path. Biol. 19, 727 (1971)Google Scholar
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    Camejo G., Lopez A., Vegas A. and Paoli A., Atherosclerosis, 21, 77 (1975)PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Cesare R. Sirtori
    • 1
  • L. Innocenti
    • 1
  • P. G. Grigolato
    • 1
  • J. Rodriguez
    • 1
  1. 1.Center E. Grossi Paloetti for the Study of Metabolic Diseases and Hyperlipidemias, and Institute of Morbid AnatomyUniversity of MilanMilanItaly

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