Turnover and Aortic Uptake of Very Low Density Lipoproteins (VLDL) from Hypercholesteremic Rabbits: Effect of Metformin
Turnover of 125I-labelled very low density lipoproteins (VLDL) from hypercholesteremic (HC) rabbits, is markedly slower than that of VLDL from control rabbits. T ½ of the two lipoproteins, in the log-normal phase, is, respectively, of 22 hours, and of 16 hrs (1). Conversion of VLDL into low density lipoproteins (LDL), and high density lipoproteins (HDL) is very rapid and almost complete in the case of normal VLDL, while HC-VLDL is very slowly converted, and, up to 48 hrs after the injection, over 60% of the radioactivity remains in the VLDL fraction. These findings, i.e. a prolonged log-normal phase, and an inefficient conversion to lipoproteins of the higher density, can be demonstrated also when labelled VLDL from HC rabbits are injected into normal recipients.
KeywordsCholesterol Arginine Metformin Triglyceride Hypothyroidism
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