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Interrelationship of Hypertension and Atherosclerosis in a Subhuman Primate Model

  • W. Hollander
  • I. M. Madoff
  • J. Paddock
  • J. Kirkpatrick
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 82)

Abstract

Hypertension is recognized as one of the major precursors of atherosclerotic vascular disease (Kannel et al. Dis. Chest. 56:43, 1969). There is evidence in man and experimental animals that a sustained elevation of arterial blood pressure regardless of its cause aggravates and accelerates atherosclerosis (Page & McGubbin Renal Hypertension. Chicago, Year Book Medical Publishers, 1968; McGill Lab. Invest. 18:463, 1968). The actual mechanism by which hypertension aggravates atherosclerosis has not been established. It also is not clear that hypertension per se, in the absence of other atherogenic factors can cause atherosclerosis. The present study was undertaken to clarify some of the interrelationships of hypertension and atherosclerosis in a subhuman primate model with hypertension.

Keywords

CYNOMOLGUS Monkey Atherogenic Diet Atherosclerotic Vascular Disease Book Medical Publisher Hypertensive Retinopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • W. Hollander
    • 1
  • I. M. Madoff
    • 1
  • J. Paddock
    • 1
  • J. Kirkpatrick
    • 1
  1. 1.Boston University Medical CenterBostonUSA

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