Interrelationship of Hypertension and Atherosclerosis in a Subhuman Primate Model
Hypertension is recognized as one of the major precursors of atherosclerotic vascular disease (Kannel et al. Dis. Chest. 56:43, 1969). There is evidence in man and experimental animals that a sustained elevation of arterial blood pressure regardless of its cause aggravates and accelerates atherosclerosis (Page & McGubbin Renal Hypertension. Chicago, Year Book Medical Publishers, 1968; McGill Lab. Invest. 18:463, 1968). The actual mechanism by which hypertension aggravates atherosclerosis has not been established. It also is not clear that hypertension per se, in the absence of other atherogenic factors can cause atherosclerosis. The present study was undertaken to clarify some of the interrelationships of hypertension and atherosclerosis in a subhuman primate model with hypertension.
KeywordsCholesterol Foam Mucopolysaccharide
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