Aortic Protocollagen Proline Hydroxylase

  • K. Grasedyck
  • J. Lindner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 82)


Hydroxyproline and hydroxylysine are not utilized for collagen synthesis by smooth muscle cells as well as by fibro-, chondro-, osteoblasts and other collagen synthesizing cells. First, the peptide chain containing proline and lysine is synthesized. The hydroxylation of these amino acids begins during the assembly and is continued after the release of the polypeptide. Protocollagen proline hydroxylase (PPH) and protocollagen lysine hydroxylase (PLH) are involved in this hydroxylation process. Figure 1 demonstrates the role of these two enzymes although their activity levels do not run parallel to the total collagen synthesis. Therefore they are regarded as key enzymes although their activity levels do not run parallel to the total collagen synthesis in any case. The above subject was discussed in some detail elsewhere (GRASEDYCK et al., 1974).


Collagen Synthesis Incorporation Rate Indicator Method Connective Tissue Metabolism Hydroxylation Process 
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  1. GRASEDYCK, K., M. HELLE, J. LINDNER, K. LANGNESS: Kriterien der Aktivität einer pathologischen Bindegewebsvermehrung bei chronischen Lebererkrankungen. Verh. Dtsch. Ges. Inn. Med. 80, 503–506 (1974).PubMedGoogle Scholar
  2. HUTTON, J.J., A.L. TAPPEL, S. UDENFRIEND: A rapid assay for collagen proline hydroxylase. Anal. Biochem. 16, 384–394 (1966).CrossRefGoogle Scholar
  3. LANGNER, R.O., G.C. FULLER: Collagen synthesis in thoracic aortas of rabbits with epinephrine-thyroxine induced arteriosclerosis. Atherosclerosis 17, 463–469 (1973).PubMedCrossRefGoogle Scholar
  4. LINDNER, J.: Regressive und progressive arterielle Reaktionen bei Atherosklerose: 5.Veränderungen im extrazellulären Kompartment. Verh. Dtseh. Ges. Inn. Med. 78, 1166–1176 (1972).Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • K. Grasedyck
    • 1
  • J. Lindner
    • 1
  1. 1.I. Med. Clinic and PathologicalInstitute University of HamburgHamburgGermany

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