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Regional Myocardial Perfusion: Studies with 133Xenon and a Multiple-Crystal Scintillation Camera

  • Paul J. Cannon
  • Melvin B. Weiss
  • Kent Ellis
  • William J. Casarella
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 82)

Abstract

Because it is impossible to measure the balance between coronary blood flow and the metabolic needs of the myocardium for oxygen by exclusively radiographic means, investigators in this laboratory developed a technique to make quantitative estimates of capillary blood flow in multiple areas of the human myocardium using 133xenon and a multiple-crystal scintillation camera (1–3). The purpose of this report is to present preliminary results of studies of 175 patients who were studied at Columbia University. The regional myocardial perfusion rates obtained with the method were correlated with radiographic assessments of the degree and the extent of the coronary disease in each patient.

Keywords

Myocardial Blood Flow Blood Flow Rate Coronary Lesion Myocardial Oxygen Consumption Atrial Pace 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Cannon, P.J., Haft, J.I. and Johnson, P.M. Visual assessment of regional myocardial perfusion using radioactive xenon and scintillation photography. Circulation 40: 277. 1969PubMedGoogle Scholar
  2. 2.
    Cannon, P.J., Dell, R.B., and Dwyer, E.M., Jr. Regional myocardial perfusion in man. J. Clin. Invest. 49: 16a, 1970.Google Scholar
  3. 3.
    Cannon, P.J., Dell, R.B. and Dwyer, E.M., Jr. Measurement of regional myocardial perfusion in man with 133xenon and a scintillation camera. J. Clin. Invest. 51 964. 1972.PubMedCrossRefGoogle Scholar
  4. 4.
    Judkins, M.P. Selective coronary arteriography. I. A percutaneous transfemoral technicque. Radiology. 89: 815. 1967.PubMedGoogle Scholar
  5. 5.
    Abrams, H.L., Editor. Angiography. Little Brown and Co. 2nd Edition. 1: 421. 1967Google Scholar
  6. 6.
    Cannon, P.J., Sciacca, R.R., Fowler, D.L., Weiss, M.B., Schmidt, D.H. and Casarella, W.J. Regional myocardial blood flow in man: description and critique of the method using 133xenon and a scintillation camera. In press. Am. J. of Cardiol.Google Scholar
  7. 7.
    Kety, S.S. I. Blood-tissue exchange methods. Theory of blood-tissue exchange and its applicaton to measurement of blood flow. Methods Med. Res. 8 223. 1960.Google Scholar
  8. 8.
    Conn, H.L., Jr. Equilibrium distribution of radioxenon in tissue: xenon-hemoglobin association curve. J. Appl. Physiol. 16: 1065. 1961PubMedGoogle Scholar
  9. 9.
    Herd, J.A., Hollenberg, M., Thorburn, G.D., Kopald, H.H. and Barger, A.C. Myocardial blood flow determined with Krypton85 in unanesthetized dogs. Am. J. Physiol. 203: 122. 1962PubMedGoogle Scholar
  10. 10.
    Ross, R.S., Ueda, K., Lichtlen, P.R. and Rees, J.R. Measurement of myocardial blood flow in animals and man by selective injection of radioactive inert gas into the coronary arteries. Circ. Res. 15: 28. 1964.PubMedGoogle Scholar
  11. 11.
    Bassingthwaighte, J.B., Strandell, T. and Donald, D.E. Estimation of coronary blood flow by washout of diffusible indicators. Circ. Res. 23: 259. 1968.PubMedGoogle Scholar
  12. 12.
    Shaw, D.J., Pitt, A. and Friesinger, G.C. Autoradiographic study of the 133xenon disappearance method for measurement of myocardial blood flow. Cardiovasc. Res. 6: 268. 1971.CrossRefGoogle Scholar
  13. 13.
    Steel, R.G.D. and Torrie, J.H. Principles and procedures of statistics. McGraw-Hill Book Co., Inc. New York, 1960.Google Scholar
  14. 14.
    Cannon, P.J., Schmidt, D.H., Weiss, M.B., Fowler, D.L., Sciacca, R.R., Ellis, K. and Casarella, W.J. The relationship between regional myocardial perfusion at rest and arteriographic lesions in patients with coronary atherosclerosis. In press. J. Clin. Invest.Google Scholar
  15. 15.
    Cannon, P.J., Dell, R.B. and Dwyer, E.M., Jr. Regional myocardial perfusion rates in patients with coronary artery disease. J. Clin. Invest. 51: 978.Google Scholar
  16. 16.
    Casarella, W.J., Weiss, M.B., Sciacca, R.R., Fowler, D.L. and Cannon, P.J. Myocardial blood flow in patients with left anterior descending disease. Submitted, 48th Scientific Sessions of the American Heart Assoc. Anaheim, Calif. 1975.Google Scholar
  17. 17.
    Klocke, F.J., Bunnell, I.L., Green, D.G., Wittenberg, S.M. and Visco, J.P. Average coronary blood flow per unit weight of left ventricle in patients with and without coronary artery disease. Circulation 50: 547. 1974.PubMedGoogle Scholar
  18. 18.
    Weiss, M.B., Ellis, K., Sciacca, R.R., Schmidt, D.H. and Cannon, P.J. Myocardial blood flow in congestive and hypertrophic cardiomyopathy: relationship to peak wall stress and mean velocity of circumferential fiber shortening. Submitted for publication.Google Scholar
  19. 19.
    Schmidt, D.H., Weiss, M.B., Casarella, W.J., Fowler, D.L., Sciacca, R.R. and Cannon, P.J. Regional myocardial perfusion during atrial pacing in patients with coronary artery disease. Submitted for publication.Google Scholar
  20. 20.
    Katz, I.N., and Feinberg, H. The relation of cardiac effort to myocardial oxygen consumption and coronary flow. Circulation 6: 656. 1954.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Paul J. Cannon
    • 1
  • Melvin B. Weiss
    • 1
  • Kent Ellis
    • 1
  • William J. Casarella
    • 1
  1. 1.The Departments of Medicine and Radiology, College of Physicians and SurgeonsColumbia UniversityN.Y.C.USA

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