Uptake of Labelled Cholesterol by Organizing Thrombus

  • Bernard I. Weigensberg
  • Robert H. More
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 82)


In previous studies (1–7) it was shown that non-occlusive white mural thrombus induced by a catheter inserted into the abdominal aortae of rabbits organized into raised fibrofatty type atherosclerotic lesions which have also been referred to as thromboatherosclerotic lesions, a term denoting their origin. Histological and chemical studies in normolipidemic rabbits (4,5, 7) showed that the lesions contained appreciable amounts of various lipids including anisotropic clefts and needles of cholesterol. Quantitative analysis of these raised lesions at various time intervals show the free cholesterol and cholesterol ester tissue concentrations summarized in Figure 1 (8).


Atherosclerotic Lesion Aortic Wall Evans Blue Cholesterol Uptake Normal Wall 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Bernard I. Weigensberg
    • 1
  • Robert H. More
    • 1
  1. 1.Department of PathologyMcGill UniversityMontrealCanada

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