Abstract
The action of vitamin D on the intestinal absorption of phosphorus has not been studied extensively in man. Limitations in the use of 32P labeled phosphate have restricted observations in large part to those of net absorption derived from metabolic balance techniques. Using such methods, Stanbury and Lumb (1) and Stanbury (2) reported that pharmacologic doses of vitamin D promoted equimolar increments in the net absorption of calcium and phosphorus in patients with advanced renal failure and severe bone disease. Such a relationship between the absorption of calcium and that of phosphorus supports the viewpoint that phosphate transport across the intestine is dependent upon that of calcium. Recent studies in the rat and chick indicate that vitamin D or its active forms stimulates intestinal transport of phosphorus independent of an effect on calcium (3, 4). In the present study, we have evaluated the effect of treatment with 1,25-dihydroxy-vitamin D3 (1,25 (OH)2D3) or 1α-hydroxy-vitamin D3 (1α(OH)D3) on net absorption of phosphorus in patients with advanced renal failure and normal volunteers. The results in man indicate that both analogs of vitamin D enhance the intestinal net absorption of phosphorus.
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References
Stanbury, S.W. and Lumb, G.A.: Metabolic studies of renal osteodystrophy. I. Calcium, phosphorus and nitrogen metabolism in rickets, osteomalacia and hyperparathyroidism complicating chronic uremia and in osteomalacia of the adult Fanconi Syndrome. Medicine 41:1, 1962.
Stanbury, S.W.: The phosphate ion in chronic renal failure. IN. D.J. Hioco, Ed., Phosphate Inorganique, Biologie et Physiopathologie, International Symposium. (Sandoz), Paris, p. 187, 1970.
Wasserman, R.H. and Taylor, A.N.: Intestinal absorption of phosphate in the chick: Effect of vitamin D3 and other parameters. J. Nutrit. 103:586, 1973.
Chen, T.C., Castillo, L., Korycka-Dahl, M., and DeLuca, H.F.: Role of vitamin D metabolites in phosphate transport of rat intestine. J. Nutrit. 104:1056, 1974.
Kopple, J.D. and Coburn, J.W.: Metabolic studies of low protein diets in uremia. II. Calcium, phosphorus and magnesium. Medicine 52:597, 1973.
Norman, A.W., Midgett, R.J., Myrtle, J.F., and Nowicki, H.G.: Studies on calciferol metabolism. I. Production of vitamin D metabolite 4B from 25-OH-cholecalciferol by kidney homogen-ates. Biochem. Biophys. Res. Commun. 42:1082, 1971.
Mitra, M.N., Norman, A.W., and Okamura, W.: Studies on vitamin D and its analogs. I. Synthesis of 1α-hydroxycholes-5-ene. J. Organic Chem. 39:2931, 1974.
Brickman, A.S., Coburn, J.W., Massry, S.G., and Norman, A.W.: 1,25 Dihydroxy-vitamin D3 in normal man and patients with renal failure. A.n. Intern. Med. 80:161, 1974.
Coburn, J.W., Hartenbower, D.L., Brickman, A.S., Massry, S.G., and Kopple, J.D.: Intestinal absorption of calcium, magnesium and phosphorus in chronic renal insufficiency. In D.S. David, Ed. Calcium Metabolism in Renal Disease, John Wiley & Sons, New York, 1977 (In Press).
Stamp, T.C.B.: The intestinal absorption of phosphorus. Its relation to calcium absorption and to treatment with vitamin D in osteomalacia, parathyroid dysfunction and chronic renal failure. Abstracts, Medical Research Society, London, 1972, p. 16P.
Caniggia, A., Sennari, C., Bencini, M., and Palazzuoli, V.: Intestinal absorption of radiophosphate in osteomalacia before and after vitamin D treatment. Calcif. Tissue Res. 2:299, 1968.
Harrison, H.E. and Harrison, H.C.: Intestinal transport of phosphate: Action of vitamin D, calcium and potassium. Amer. J. Physiol. 201:1007, 1961.
Heibock, H.J., Forte, J.G., and Saltman, P.: The mechanism of calcium transport by rat intestine. Biochim. Biophys. Acta. 126:81, 1966.
Kowarski, S. and Schachter, D.: Effects of vitamin D on phosphate transport and incorporation into mucosal constituents of rat intestinal mucosa. J. Biol. Chem. 244:211, 1969.
Walling, M.W. and Kimberg, D.V.: Effects of 1α, 25-Dihydroxy-vitamin D3 and Solanum glaucophyllum on intestinal calcium and phosphate transport and on plasma Ca, Mg, and P levels in the rat. Endocrinology. 97:1567, 1975.
Cramer, CF.: In vivo measurement of radiophosphorus and radiostrontium absorption in rats. Proc. Soc. Exptl. Biol. Med. 100:364, 1959.
Thompson, V. and DeLuca, H.F.: Vitamin D and phospholipid metabolism. J. Biol. Chem. 239:984, 1963.
Hurwitz, S. and Bar, A.: Site of action of vitamin D. Amer. J. Physiol. 222:761, 1972.
Brickman, A.S., Sherrard, D.J., Jowsey, J., Singer, F.R., Baylink, D.J., Maloney, N., Massry, S.G., Norman, A.W., Coburn, J.W.: 1,25-Dihydroxycholecalciferol. Effect on skeletal lesions and plasma parathyroid hormone levels in uremic osteodystrophy. Arch. Intern. Med. 134:883, 1974.
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Coburn, J.W., Brickman, A.S., Hartenbower, D.L., Norman, A.W. (1977). Intestinal Phosphate Absorption in Normal and Uremic Man: Effects of 1,25(OH)2-Vitamin D3 and 1α(OH)-Vitamin D3 . In: Massry, S.G., Ritz, E. (eds) Phosphate Metabolism. Advances in Experimental Medicine and Biology, vol 81. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-4217-5_53
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DOI: https://doi.org/10.1007/978-1-4613-4217-5_53
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