Abstract
The term idiopathic hypercalciuria was originally used to describe the condition, characterized by hypercalciuria, normocalcemia and recurrent calcium (Ca) nephrolithiasis, for which no clear-cut etiology for the hypercalciuria could be found.1 It is now recognized that this condition comprises a mixed group consisting of separate entities. Two subtypes,- renal hypercalciuria (RH) and absorptive hypercalciuria (AH), have now been well-characterized, depending on whether the hypercalciuria is the consequence of an impaired renal tubular reabsorption of Ca2 or the intestinal hyper-absorption of Ca.3,4 The objective of this discussion is to review diagnostic criteria, causes for the hypercalciuria and therapeutic considerations in renal and absorptive hypercalciurias.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Henrieman, P.H., Benedict, P.H., Forbes, A.P., and Dudley, H.R.: Idiopathic hypercalciuria. New Engl. J. Med. 259:802, 1958.
Coe, F.L., Canterbury, J.M., Firpo, J.J., and Reiss, E.: Evidence for secondary hyperparathyroidism in idiopathic hypercalciuria. J. Clin. Invest. 52:134, 1973.
Nordin, B.E.C., Peacock, M., and Wilkinson, R.: Hypercalciuria and calcium stone disease. Clinics in Endocrinol. Metab. 1:169, 1972.
Pak, C.Y.C., Ohata, M., Lawrence, E.C., and Snyder, W.: The hypercalciurias: causes, parathyroid functions and diagnostic criteria. J. Clin. Invest. 52:387, 1974.
Pak, C.Y.C., Kaplan, R.A., Townsend, J., and Waters, O.: A simple test for the diagnosis of absorptive, resorptive, and renal hypercalciurias. New Engl. J. Med. 292:497, 1975.
Pak, C.Y.C., Barilla, D., Bone, H., and Northcutt, C: Medical management of renal calculi. Presented at the symposium Advances in Endocrinology and Metabolism, Hahnemann Medical College and Hospital of Philadelphia, Philadelphia, Pennsylvania. February 24, 1976. In press.
Haussler, M.R., Bursac, K.M., Bone, H., and Pak, C.Y.C.: Increased circulating 1α,25-dihydroxyvitamin D3 in patients with primary hyperparathyroidism. Clin. Res. 23:322A, 1975.
Barilla, D.E., Tolentino, R., Kaplan, R.A., and Pak, C.Y.C.: Selective effects of hydrochlorothiazide on the intestinal absorption of calcium in absorptive and renal hypercalciurias. Submitted for publication.
Kaplan, R.A., Haussler, M.R., and Pak, C.Y.C.: The role of 1α, 25-hydroxycholecalciferol in the mediation of intestinal hyper-absorption of calcium in primary hyperparathyroidism and hyper-calciuria. Submitted for publication.
Fordtran, J.S., and Pak, C.Y.C.: Preliminary observations.
Vergne-Marini, P., Parker, T.F., Pak, C.Y.C., Hull, A.R., De-Luca, H.F., and Fordtran, J.S.: Jejunal and ileal calcium absorption in patients with chronic renal disease. Effect of 1α-hydroxycholecalciferol. J. Clin. Invest. 57:861, 1976.
Shen, F., Baylink, D., Nielson, R., Hughes, M., and Haussler, M.: Increased serum 1,25-dihydroxycholecalciferol (1,25-diOHD3) in patients with idiopathic hypercalciuria (IH). Clin. Res. 23:423A, 1975.
Pak, C.Y.C., Delea, CS., and Bartter, F.C.: Successful treatment of recurrent nephrolithiasis (calcium stones) with cellulose phosphate. New Engl. J. Med. 290:175, 1974.
Pak, C.Y.C.: Physicochemical and clinical aspects of nephrolithiasis. Symposium of International Colloquium on Renal Lithia-sis. Univeristy of Florida, Gainesville, Fla. 1974. In press.
Brickman, A.S., Massry, S.G., and Coburn, J.W.: Changes in serum and urinary calcium during treatment with hydrochlorothiazide: studies on mechanisms. J. Clin. Invest. 51:945, 1972.
Pak, C.Y.C.: Hydrochlorothiazide therapy in nephrolithiasis: effect on urinary activity product and formation product of brushite. Clin. Pharm. Therap. 14:209, 1973.
Woelfel, A., and Pak, C.Y.C.: Effect of hydrochlorothiazide on the crystallization of calcium oxalate in urine. Submitted for publication.
Pak, C.Y.C., Ruskin, B., and Diller, E.: Enhancement of renal excretion of zinc by hydrochlorothiazide. Clin. Chim. Acta 39: 511, 1972.
Pak, C.Y.C.: Sodium cellulose phosphate: mechanism of action and effect on mineral metabolism. J. Clin. Pharm. New Drug 13:15, 1973.
Hayashi, Y., Kaplan, R.A., and Pak, C.Y.C.: Effect of sodium cellulose phosphate therapy on crystallization of calcium oxalate in urine. Metabolism 24:1273, 1975.
Pak, C.Y.C.: Effects of cellulose phosphate and of sodium phosphate on the formation product and activity product of brushite in urine. Metabolism 21:447, 1972.
Fleisch, H. and Bisazl S.: Isolation from urine of pyrophosphate, a calcification inhibitor. Amer. J. Physiol. 203:671. 1962.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Springer Science+Business Media New York
About this chapter
Cite this chapter
Pak, C.Y.C. (1977). Idiopathic Hypercalciuria. In: Massry, S.G., Ritz, E. (eds) Phosphate Metabolism. Advances in Experimental Medicine and Biology, vol 81. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-4217-5_30
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4217-5_30
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4613-4219-9
Online ISBN: 978-1-4613-4217-5
eBook Packages: Springer Book Archive