Abstract
Hypophosphatemia and hyperphosphaturia have been observed in renal transplant patients (1). Numerous factors can affect urinary phosphate excretion in the post-transplant state, but PTH is probably the most important. The persistence of an elevated SPTH level in the post-transplant period, despite good allograft function, suggests that phosphaturia may be directly related to the hyper-parathyroid state. Since PTH-induced phosphaturia is mediated by cAMP (2), there should be a correlation between SPTH and urinary cAMP excretion (UcAMP). Our study was initiated with the following objectives:
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a.
To correlate the level of allograft function (determined by endogenous creatinine clearance, Ccreat) and SPTH concentration.
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b.
To define the relationship between SPTH level and UCAMP-
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c.
To correlate phosphate handling by the allograft with SPTH and UCAMP excretion.
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© 1977 Springer Science+Business Media New York
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Ward, H.N., Pabico, R.C., McKenna, B.A., Freeman, R.B. (1977). The Renal Handling of Phosphate by Renal Transplant Patients: Correlation with Serum Parathyroid Hormone (SPTH), Cyclic 3′,5′-Adenosine Monophosphate (cAMP) Urinary Excretion, and Allograft Function. In: Massry, S.G., Ritz, E. (eds) Phosphate Metabolism. Advances in Experimental Medicine and Biology, vol 81. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-4217-5_20
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DOI: https://doi.org/10.1007/978-1-4613-4217-5_20
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