Advertisement

Immunochemistry of Collagen

  • Dov Michaeli

Abstract

Vertebrate collagen (Fig. IB) is made up of three polypetide chains (designated α-chains), each of about 1000 amino acid residues and having a molecular weight of about 95,000. Each chain is coiled in a left-handed helix, and the three chains are coiled in a right-handed superhelix. The triple-stranded, coiled-coil structure is rod shaped, having the dimensions of 3000 x 15 Å. Chemical studies established that the three component polypeptide chains extend in parallel the full length of the molecule.

Keywords

Collagen Type Antigenic Determinant Skin Collagen Antigenic Activity Helical Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arnon, R., and Sela, M., 1960, Biochem. J. 75: 103.PubMedGoogle Scholar
  2. Becker, U., Timpl, R., and Kühn, K., 1972, Eur. J. Biochem. 28: 221.PubMedGoogle Scholar
  3. Becker, U., Furthmayr, H., and Timpl, R., 1975, Hoppe-Seyler’s Z. Physiol. Chem. 356: 21.Google Scholar
  4. Beil, W., Furthmayr, H., and Timpl, R., 1972, Immunochemistry 9: 779. 396Google Scholar
  5. Beil, W., Timpl, R., and Furthmayr, H., 1973, Immunology 24: 13.PubMedGoogle Scholar
  6. Benjamini, E., Michaeli, D., Leung, C. Y. K., Wong, K., and Scheuenstuhl, H., 1973, Immunochemistry 10: 629.PubMedGoogle Scholar
  7. Borek, F., Kurtz, J., and Sela, M., 1969, Biochim. Biophys. Acta 188: 314.PubMedGoogle Scholar
  8. Bornstein, P., 1968, Science 161: 592.PubMedGoogle Scholar
  9. Bornstein, P., 1969, Biochemistry 8: 63.PubMedGoogle Scholar
  10. Bornstein, P., 1974, The biosynthesis of collagen, in: Annual Review of Biochemistry ( E. E. Snell, P. D. Boyer, A. Meister, and R. L. Sinsheimer, eds.), pp. 567–603, Annual Reviews Inc., Palo Alto, Calif.Google Scholar
  11. Bornstein, P., and Nesse, R., 1970, Arch. Biochem. Biophys. 138: 443.PubMedGoogle Scholar
  12. Chidlow, J. W., Bourne, F. J., and Bailey, A. J., 1974, Immunology 27: 665.PubMedGoogle Scholar
  13. Chung, E., Keele, E. M., and Miller, E. J., 1974, Biochemistry 13: 3459.PubMedGoogle Scholar
  14. Click, E. M., and Bornstein, P., 1970, Biochemistry 9: 4699.PubMedGoogle Scholar
  15. Cracchiolo, A., Michaeli, D., Goldberg, L. S., and Fudenberg, H. H., 1975, Clin. Immunol. Immunopathol. 3: 567.PubMedGoogle Scholar
  16. Daniels, J. R., and Chu, G. H., 1975, J. Biol. Chem. 250: 3531.PubMedGoogle Scholar
  17. Davison, P. F., Levine, L., Drake, M. P., Rubin, A., and Bump, S., 1967, J. Exp. Med. 126: 331.PubMedGoogle Scholar
  18. Dehrn, P., Olsen, B., and Prockop, D., 1974, Eur. J. Biochem. 46: 107.Google Scholar
  19. Engl, J., Kurtz, J., Katchalski, E., and Berger, A., 1966, J. Mol. Biol. 17: 255.Google Scholar
  20. Epstein, E. H., Jr., 1974, J. Biol. Chem. 249: 3225.PubMedGoogle Scholar
  21. Epstein, E. H., Jr., Scott, R. D., Miller, E. J., and Piez, K. A., 1971, J. Biol. Chem. 246: 1718.PubMedGoogle Scholar
  22. Feldmann, M., and Basten, A., 1971, J. Exp. Med. 134: 103.PubMedGoogle Scholar
  23. Fietzek, P. P., and Kühn, K., 1976, The primary structure of collagen, in: International Review of Connective Tissue Research, Vol. 7, Academic Press, New York, pp. 1–60.Google Scholar
  24. Fuchs, S., and Harrington, W. F., 1970, Biochim. Biophys. Acta 221: 119.PubMedGoogle Scholar
  25. Fuchs, S., Maoz, A., and Sela, M., 1974a, Isr. J. Chem. 12: 681.Google Scholar
  26. Fuchs, S., Mozes, E., Maoz, A., and Sela, M., 1974b, J. Exp. Med. 139: 148.Google Scholar
  27. Furthmayr, H., and Timpl, R., 1972, Biochem. Biophys. Res. Commun. 47: 944.Google Scholar
  28. Furthmayr, H., and Timpl, R., 1975, Immunochemistry of collagens and procollagens, in: International Review of Connective Tissue Research, Vol. 7, Academic Press, New York, 1976, pp. 61–99.Google Scholar
  29. Furthmayr, H., Beil, W., and Timpl, R., 1971, FEBS Lett. 12: 341.PubMedGoogle Scholar
  30. Furthmayr, H., Stoltz, M., Becker, U., Beil, W., and Timpl, R., 1972, Immunochemistry 9: 789.PubMedGoogle Scholar
  31. Gallop, P. M., Blumenfeld, O. O., and Seifter, S., 1972, Structure and metabolism of connective tissue proteins, in: Annual Review of Biochemistry ( E. E. Snell, P. D. Boyer, A. Meister, and C. C. Richardson, eds.), pp. 617–672, Annual Reviews Inc., Palo Alto, Calif.Google Scholar
  32. Gay, S., and Adelmann, B. C., 1974, Z. Immun. Allergieforsch. 147: 315.Google Scholar
  33. Gay, S., Fietzek, R. P., Remberger, K., Eder, M., and Kühn, K., 1975, Klin. Wochenschr. 53: 205.PubMedGoogle Scholar
  34. Hahn, E., and Timpl, R., 1973, Eur. J. Immunol. 3: 442.PubMedGoogle Scholar
  35. Hahn, E., Timpl, R., and Miller E. J., 1974, J. Immunol. 113: 421.PubMedGoogle Scholar
  36. Hahn, E., Timpl, R., and Miller, E. J., 1975a; Immunology 28: 561.Google Scholar
  37. Hahn, E., Nowack, H., Götze, D., and Timpl, R., 1975b, Eur. J. Immunol. 5: 288.Google Scholar
  38. Haimovich, J., and Sela, M., 1966, J. Immunol. 94: 388.Google Scholar
  39. Hopper, K., Adelmann, B. C., Gentner, G., and Gay, S., 1974, Z. Immun. Allergieforsch. 147: 316.Google Scholar
  40. Jasin, H. E., and Glynn, L. E., 1965a, Immunology 8: 95.Google Scholar
  41. Jasin, H. E., and Glynn, L. E., 1965b, Immunology 8: 260.Google Scholar
  42. Kang, A. H., Bornstein, P., and Piez, K. A., 1967, Biochemistry 6: 788.PubMedGoogle Scholar
  43. Kang, A. H., and Gross, J., 1970, Biochemistry 9: 796.PubMedGoogle Scholar
  44. Kefalides, N. A., 1970, Comparative biochemistry of mammalian basement membranes, in: Chemistry and Molecular Biology of the Intercellular Matrix ( E. A. Balazs, ed.), pp. 535–573, Academic Press, New York.Google Scholar
  45. Kefalides, N. A., 1974, J. Clin. Invest. 53: 403.PubMedGoogle Scholar
  46. Kettman, J. R., Benjamini, E., Michaeli, D., and Leung, D. Y. K., 1967, Biochem. Biophys. Res. Commun. 29: 623.PubMedGoogle Scholar
  47. Kirrane, J. A., and Glynn, L. E., 1968, Immunology of collagen, in: International Review of Connective Tissue Research (D. A. Hall, ed.), pp. 1–31, Vol. 4, Academic Press, New York.Google Scholar
  48. Kirrane, J. A., and Van B. Robertson, W., 1968, Immunology 14: 139.PubMedGoogle Scholar
  49. Knapp, W., Menzel, J., Brunner, H., and Steffen, C., 1974, Z. Immun. Allergieforsch. 146: 283.Google Scholar
  50. Kühn, K., 1969, The structure of collagen, in: Essays in Biochemistry, Vol. 5 ( P. N. Campbell, and G. D. Greville, eds.), pp. 59–87, Academic Press, New York.Google Scholar
  51. Lenaers, A., Ansay, M., Nusgens, B. V., and Lapière, C. M., 1971, Eur, J. Biochem. 23: 533.Google Scholar
  52. LeRoy, C. E., 1968, Proc. Soc. Exp. Biol. Med. 128: 341.PubMedGoogle Scholar
  53. LeRoy, C. E., 1969, J. Immunol. 102: 919.PubMedGoogle Scholar
  54. Lindsley, H. B., Mannik, M., and Bornstein, P., 1969, Arthritis Rheum. 12: 676.Google Scholar
  55. Lindsley, H., Mannik, M., and Bornstein, P., 1971, J. Exp. Med. 133: 1309.PubMedGoogle Scholar
  56. Maoz, A., Fuchs, S., and Michaeli, D., 1971, Biochim. Biophys. Acta 243: 106.PubMedGoogle Scholar
  57. Maoz, A., Fuchs, S., and Michaeli, D., 1971, Biochim. Biophys. Acta 243: 106.PubMedGoogle Scholar
  58. Maoz, A., Dym, H., Fuchs, S., and Sela, M., 1973a, Eur. J. Immunol. 3: 839.Google Scholar
  59. Maoz, A., Fuchs, S., and Sela, M., 1973b, Biochemistry 12: 4238.Google Scholar
  60. Maoz, A., Fuchs, S., and Sela M., 1973c, Biochemistry 12: 4246.Google Scholar
  61. Martin, G. R., Byers, P. H., and Piez, K. A., 1975, Advan. Enzymol. 42: 167.Google Scholar
  62. McBride, O. W., and Harrington, W. F., 1967, Biochemistry 6: 1484.PubMedGoogle Scholar
  63. Meigel, W., Pontz, B., Timpl, R., Hieber, E., Nordwig, A., Steffen, C., and Kühn, K., 1971, J. Immunol. 107: 1146.PubMedGoogle Scholar
  64. Michaeli, D., and Epstein, E. H., 1971, Isr. J. Med. Sci. 7: 462.PubMedGoogle Scholar
  65. Michaeli, D., and Fudenberg, H. H., 1974a, Clin. Immunol. Immunopathol. 2: 153.Google Scholar
  66. Michaeli, D., and Fudenberg, H. H., 1974b, Clin. Immunol. Immunopathol. 3: 187.Google Scholar
  67. Michaeli, D., Kamenecka, H., Benjamini, E., Kettman, J. R., Leung, D. Y. K., and Miner, R. C., 1968, Immunochemistry 5: 433.Google Scholar
  68. Michaeli, D., Martin, G. R., Kettman, J., Benjamini, E., Leung, D. Y. K., and Blatt, B. A., 1969, Science 166: 1522.PubMedGoogle Scholar
  69. Michaeli, D., Martin, G. R., and Benjamini, E., 1970, Localization of the antigenic determinants of collagen, in: Chemistry and Molecular Biology of the Intercellular Matrix, Vol. 1 ( E. A. Balazs, ed.), pp. 275–278, Academic Press, New York.Google Scholar
  70. Michaeli. D., Benjamini, E., and Leung, D. Y. K., 1971, Immunochemistry 8: 1.PubMedGoogle Scholar
  71. Michaeli, D., Senyk, G., Maoz, A., and Fuchs, S., 1972, Immunol. 109: 103.Google Scholar
  72. Miller, E. J., 1971, Biochemistry 10: 1652.PubMedGoogle Scholar
  73. Miller, E. J., Woodall, D. L., and Vail, M. S., 1973, J. Biol. Chem. 248: 1666.PubMedGoogle Scholar
  74. Nordwig, A., Nowack, H., and Hieber-Rogall, E., 1973, J. Mol. Evol. 2: 175.PubMedGoogle Scholar
  75. Nowack, H., Timpl, R., and Nordwig, A., 1974, Eur. J. Immunol. 4: 698.PubMedGoogle Scholar
  76. Nowack, H., Hahn, E., David, C. S., Timpl, R., and Götze, D., 1975a, Immunogenetics 2: 331.Google Scholar
  77. Nowack, H., Hahn, E., and Timpl, R., 1975b, Immunology 29: 621.Google Scholar
  78. O’Dell, D. S., 1968, Immunology of collagen and related materials, in: Treatise on Collagen, Vol. 2 ( B. S. Gould, ed.), pp. 311–322, Part A, Academic Press, New York.Google Scholar
  79. Olsen, B. R., and Prockop, D. J., 1974, Proc. Natl. Acad. Sci. U.S.A. 71: 2033.PubMedGoogle Scholar
  80. Pontz, B., Meigel, W., Rauterberg, J., and Kühn, K., 1970, Eur. J. Biochem. 16: 50.PubMedGoogle Scholar
  81. Rauterberg, J., and Kuhn., 1971, Eur. J. Biochem. 19: 398.PubMedGoogle Scholar
  82. Rauterberg, J., Timpl, R., and Furthmayr, H., 1972, Eur. J. Biochem. 27: 231.PubMedGoogle Scholar
  83. Rothbard, S., and Watson, R. F., 1961, J. Exp. Med. 113: 1041.PubMedGoogle Scholar
  84. Rothbard, S., and Watson, R. F., 1965, J. Exp. Med. 122: 441.PubMedGoogle Scholar
  85. Rothbard, S., and Watson, R. F., 1967, J. Exp. Med. 125: 595.PubMedGoogle Scholar
  86. Schmitt, F. 0., Levine, L., Drake, M. P., Rubin, A. L., Pfahl, D., and Davison, P. F., 1964, Proc. Natl. Acad. Sci. U.S.A. 51: 493.PubMedGoogle Scholar
  87. Schofeld, J. D., and Prockop, D. J., 1973, Clin. Orthop. Related Res. 93: 175.Google Scholar
  88. Sela, M., and Arnon, R., 1960a, Biochem. J. 75: 91.Google Scholar
  89. Sela, M., and Arnon, R., 1960b, Biochem. J. 77: 394.Google Scholar
  90. Senyk, G., and Michaeli, D., 1973, J. Immunol. 111: 1381.PubMedGoogle Scholar
  91. Sherr, C. J., and Goldberg, B., 1973, Science 180: 1190.PubMedGoogle Scholar
  92. Stark, M., Rauterberg, J., and Kühn, K., 1971, FEBS Lett. 13: 101.PubMedGoogle Scholar
  93. Steffen, C., 1970, Z. Immun. Allergieforsch. 139: 219.Google Scholar
  94. Steffen, C., Timpl, R., and Wolff, I., 1967a, Z. Immunitaetsforsch. 134: 91.Google Scholar
  95. Steffen, C., Timpl, R., and Wolff, I., 1967b, Z. Immunitaetsforsch. 134: 205.Google Scholar
  96. Steffen, C., Timpl, R., and Wolff, I., 1968a, Immunology 51: 135.Google Scholar
  97. Steffen, C., Schuster, F., Tausch, G., and Pecker, I., 1968b, Klin. Wochenschr. 46: 976.Google Scholar
  98. Steffen, C., Dichtl, M., Knapp, W., and Brunner, H., 1971, Immunology 21: 649.PubMedGoogle Scholar
  99. Steffen, C., Ludwig, H., Thumb, N., Frank, O., Eberl, R., and Tausch, F., 1973, Klin. Wochenschr. 51: 222.PubMedGoogle Scholar
  100. Steffen, C., Ludwig, H., and Knapp, W., 1974, Z. Immun. Allergieforsch. 147: 229.Google Scholar
  101. Stoltz, M., Timpl, R., and Kühn, K., 1972, FEBS Lett. 26: 61.Google Scholar
  102. Stoltz, M., Timpl, R., Furthmayr, H., and Kühn, K., 1973, Eur. J. Biochem. 37: 287.PubMedGoogle Scholar
  103. Taubman, M. B., Goldberg, B., and Sherr, C. J., 1974, Science 186: 1115.PubMedGoogle Scholar
  104. Timpl, R., Wolff, I., Furthmayr, H., and Steffen, C., 1968a, Immunology 15: 145.Google Scholar
  105. Timpl, R., Wolff, I., Wick, G., Furthmayr, H., and Steffen, C., 1968b, J. Immunol. 101: 725.Google Scholar
  106. Timpl, R., Wolff, I., Meigel, W., Pontz, B., Steffen, C., and Kühn, K., 1970, J. Immunol. 105: 1131.PubMedGoogle Scholar
  107. Timpl, R., Beil, W., Furthmayr, H., Meigel, W., and Pontz, B., 1971, Immunology 21:1017.Google Scholar
  108. Timpl, R., Furthmayr, H., and Beil, W., 1972, J. Immunol. 108: 119.PubMedGoogle Scholar
  109. Timpl, R., Furthmayr, H., Hahn, E., Becker, V., and Stoltz, M., 1973a, Behring Inst. Mitt. 53: 66.Google Scholar
  110. Timpl, R., Wick, G., Furthmayr, H., Lapiere, C. M., and Kühn, K., 1973b, Eur. J. Biochem. 32: 584.Google Scholar
  111. Tkocz, C., and Kühn, K., 1969, Eur. J. Biochem. 7: 454.PubMedGoogle Scholar
  112. Traub, W., and Piez, K. A., 1971, The chemistry and structure of collagen, in: Advances in Protein Chemistry, Vol. 25 (C. B. Anfinsen, Jr., J. T. Edsall, and F. M. Richards, eds.), pp. 243–352, Academic Press, New York.Google Scholar
  113. Traub, W., and Yonath, A., 1966, J. Mol. Biol. 16: 404.PubMedGoogle Scholar
  114. von der Mark, K„ Wendt, P., Rexrodt, F., and Kuhn, K., 1970, FEBS Lett. 11: 105.PubMedGoogle Scholar
  115. von der Mark, K., Click, E. M., and Bornstein, P., 1973, Arch. Biochem. Biophys. 156: 356.PubMedGoogle Scholar
  116. Watson, R. F., Rothbard, S., and Vanamee, P., 1954, J. Exp. Med. 99: 535.PubMedGoogle Scholar
  117. Wells, J. V., Michaeli, D., and Fudenberg, H. H., 1973, Clin. Exp. Immunol. 13: 203.PubMedGoogle Scholar
  118. Wells, J. V., Michaeli, D., and Fudenberg, H. H., 1975, Auto-immunity in selective IgA deficiency, in: Birth Defects: Original Article Series (D. Bergsma and R. A. Good, eds.), Sinauer Associates, New York, Vol. 6, No. 1, pp. 144–146.Google Scholar
  119. Wick, G., Furthmayr, H., and Timpl, R., 1975, Int. Arch Allergy Appl. Immunol. 48:664.PubMedGoogle Scholar
  120. Wolff, I., Wick, G., Furthmayr, H., Timpl. R., and Steffen, C., 1970, Immunology 18: 843.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Dov Michaeli
    • 1
  1. 1.Departments of Biochemistry and Biophysics and SurgeryUniversity of California School of MedicineSan FranciscoUSA

Personalised recommendations