The Role of Ethanol Metabolites in Hepatic Lipid Peroxidation
The spectrum of alcoholic liver injury comprises three major disorders, namely fatty liver, alcoholic hepatitis and cirrhosis (1). Because the fatty liver is readily inducible in both patients and experimental animals, and is the initial event in alcohol-induced hepatic pathology, it has been the most extensively studied aspect of alcoholic liver disease. The increased lipid is primarily in the form of triglycerides and it is entirely reversible upon discontinuation of alcohol abuse (2). In spite of intensive investigative efforts, the pathogenesis of the alcohol-induced fatty liver has not yet been fully resolved (1, 3).
KeywordsLipid Peroxidation Fatty Liver Liver Homogenate Saline Control Chronic Ethanol
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