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The Biochemical Pharmacology of Mucus

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Book cover Mucus in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 89))

Abstract

The pharmacology of agents which affect mucus and its production, and of drugs used in the treatment of mucus diseases, is largely unwritten. Classical texts, such as Goodman and Gilman (1975), confine themselves to considerations of mucolytics such as ammonium chloride and acetylcysteine, which decrease sputum viscosity and enhance expectoration by salt effects or by reduction of the disulphide cross-linkages between the glycoprotein monomers of mucus.

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References

  • Amer, M.S., McKinney, G.R. and Akcasu, A. (1974) Biochem. Pharmac., 23, 3085.

    Article  Google Scholar 

  • Avery-Jones, F. and Parke, D.V. (1975). in, Fourth Carbenoxolone Symposium, Butterworth, London.

    Google Scholar 

  • Baker, A.P., Chakrin, L.W., Sawyer, J.L., Munro, J.R., Hillegrass, L.M. and Giannone, E. (1974) Biochem. Med., 10, 387.

    Article  Google Scholar 

  • Baker, A.P. and Hillegrass, L.M. (1974) Arch. Biochem. Biophys., 165, 597

    Article  Google Scholar 

  • Baker, A.P. and Sawyer, J.L. (1975) Biochem. Med., 14, 42.

    Article  Google Scholar 

  • Davenport, H.W., Warner, H.A. and Code, C.F. (1964). Gastroenterol., 47, 142

    Google Scholar 

  • Dekanski, J.B., MacDonald, A., Sacra, P. and Parke, D.V. (1975). Brit. J. Pharmac., 55, 387.

    Google Scholar 

  • Dinelli, C.A., Gironi, A., Lomazzi, A.. Montrasio, P. L. and Ratti, L. (1976). Atzneim.-Forsch., 26, 421.

    Google Scholar 

  • Dodge, P.W., Brodle, D.A., Young, P.R., Krause, R.A. and Tekeli, S. (1974). Dig. Dis., 19, 449.

    Article  Google Scholar 

  • Domschke, W., Domschke, S. and Demllng, L. (1976). Acta Hepato- Gastroenterol., 23, 213.

    Google Scholar 

  • Eichhorn, J.H., Salzman, E.W. and Silen, W. (1974). Nature, (Lond.), 248, 238.

    Article  Google Scholar 

  • Goodman, L.S. and Gilman, A. (1975). in, The Pharmacological Basis of Therapeutics, p.955 5th ed., Macmillan, New York.

    Google Scholar 

  • Havez, R., Degand, P., Roussel, P. and Randoux, A. (1970). Poumon et Coeur, 26, 81.

    Google Scholar 

  • Hietanen, E. (1975) Digest. Dis., 20, 31

    Article  Google Scholar 

  • Johnston, B., Lindup, W.E., Shillingford, J.S., Smith, M. and Parke, D.V. (1975a). in, Fourth Carbenoxolone Symposium, (Eds.) F. Avery Jones and D.V. Parke, p.3, Butterworth, London.

    Google Scholar 

  • Johnston, B., Symons, A.M. and Parke D.V. (1975b). Biochem.Soc. Trans., 3, 1112.

    Google Scholar 

  • Johnston, B. (1977). Ph.D. Thesis, University of Surrey.

    Google Scholar 

  • Kent, P.W. and Allen, A. (1968). Biochem. J., 106, 645

    Google Scholar 

  • Kesseril, E. (1973). in. Cervical Mucus in Human Reproduction, (Eds.) M. Elstein, K.S. Moghissi and R. Borth, Ch.4, Scriptor, Copenhagen.

    Google Scholar 

  • Kimberg, D.V. (1974) Gastroenterol., 67, 1023

    Google Scholar 

  • Lambadarios, C., Hastings, C., Abo-Darub, J. and Cooke, I.D. (1976). J. Reprod. Fert., 46, 383

    Article  Google Scholar 

  • Lipkin, M. (1970). in, Carbenoxolone Sodium, (Eds.) J.H. Baron and F.M. Sullivan, p.11. Butterworths, London.

    Google Scholar 

  • Lukie, B.E. and Forstner, G.G. (1972). Biochim.Biophys.Acta, 273, 380.

    Article  Google Scholar 

  • Mangla, J.C., Kim, Y.M. and Rubulis, A.A. (1974). Nature, (Lond.), 250, 61.

    Article  Google Scholar 

  • Masson, P.L. (1973). in, Cervical Mucus in Human Reproduction, (Eds.) M. Elstein, K.S. Moghissi and R. Borth. Ch.7, Scriptor, Copenhagen.

    Google Scholar 

  • McPherson, F., Bridges, J.W. and Parke, D.V. (1974). Nature, (Lond.), 252, 488

    Article  Google Scholar 

  • Menasse-Gdynia, R. and Krupp, P. (1974) Toxicol.Appl.Pharmac., 29, 389.

    Article  Google Scholar 

  • Moghissi, K.S. (1973). in, Cervical Mucus in Human Reproduction, (Eds.) M. Elstein, K.S. Moghissi and R. Borth, Ch.ll, Scriptor, Copenhagen.

    Google Scholar 

  • Oster, G.K. (1971). Nature, (Lond.), 234, 153.

    Article  Google Scholar 

  • Parke, D.V. (1977).. in, Biochemistry of Cancer, (Ed.) B.W. Raven, Plenum, London.

    Google Scholar 

  • Peskar, B.M. and Peskar, B.A. (1976). Biochim. Biophys. Acta, 424, 14 30.

    Google Scholar 

  • Rainsford, K.D. (1975). Agents and Actions, 5, 326.

    Article  Google Scholar 

  • Robert, A., Lancaster, C. and Nezamis, J.E. (1973). Gastroenterol., 64, 790.

    Google Scholar 

  • Robert, A., Nezamis, J.E. and Phillips, J.P. (1967). Am. J. Dig. Dis., 12, 1073.

    Article  Google Scholar 

  • Sander, L.D., Chandler, A.M. and Johnson, L.R. (1975). Gastroenterol. 68, 285.

    Google Scholar 

  • Shillingford, J.S. (1975). Ph.D. Thesis, University of Surrey.

    Google Scholar 

  • Sten, J. and Sting, K. (1970). Fertil. Steril., 21, 307.

    Google Scholar 

  • Symons, A.M. (1976). Biochem. Pharm., 25, 1545.

    Article  Google Scholar 

  • Sunshine, G.H., Williams, D.J. and Rabin, B.R. (1971). Nature, New Biol., 230, 133.

    Google Scholar 

  • van Beck, W.P., Smets, L.A. and Emmelot, P. (1973). Cancer Res., 33, 2913.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Surrey, Guildford, Surrey, UK

    D. V. Parke & A. M. Symons

Authors
  1. D. V. Parke
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  2. A. M. Symons
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Editor information

Editors and Affiliations

  1. Southampton General Hospital, Southampton, England

    Max Elstein

  2. University of Surrey, Guildford, England

    Dennis V. Parke

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© 1977 Plenum Press, New York

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Parke, D.V., Symons, A.M. (1977). The Biochemical Pharmacology of Mucus. In: Elstein, M., Parke, D.V. (eds) Mucus in Health and Disease. Advances in Experimental Medicine and Biology, vol 89. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4172-7_29

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  • DOI: https://doi.org/10.1007/978-1-4613-4172-7_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4174-1

  • Online ISBN: 978-1-4613-4172-7

  • eBook Packages: Springer Book Archive

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