Association of Lymphocyte Alloantigen Genotypes with Levels of Immune Responses
The association of specific immunological unresponsiveness with genes coding within the major histocompatibility complex (MHC) in mammals has been known for some time (l, 2), and was reported more recently in chickens (3, 4). It was presumed that MHC-determined surface antigens on lymphocytes, and perhaps on other immunological effectors such as macrophages, must play a major role in the mechanism of these associations (2, 5). However, direct information on the mode of action, in this context, of MHC antigens such as la, H-2D or H-2K has been forthcoming only in the last year or so (6, 7). The question of the genetic determination of differing levels of immune response among responders was extensively discussed at a meeting in 1972 (8), but this issue has not been widely followed up. We became interested in this question because of our work with two inbred lines of chickens which are identical at the B MHC, and yet exhibit marked differences in resistance to oncogenesis of lymphoid cells by exogenous viruses subsequent to the initiation of systemic infection. Chickens from East Lansing inbred line 6 (EL6) develop only a very low incidence of Marek’s disease (MD) or of Lymphoid Leukosis (LL) following exposure to the appropriate virus by inoculation or contact (9, 10).
KeywordsMajor Histocompatibility Complex Inbred Line Spleen Weight High Responder Major Histocompatibility Complex Allele
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