Summary
Genetic analysis and in vivo and in vitro biochemical studies have revealed that radiation and most chemical mutagens induce in bacteria an error-prone DNA repair process which is responsible for their mutagenic effect. This repair process, called SOS repair, has been correlated with an increased cellular capacity to replicate damaged DNA by permitting insertions of non complementary nucleotides opposite DNA lesions. The crucial role of the 3′ → 5′ exonuclease (“proof-reading”) activity has been elucidated. Unlike E.coli DNA polymerases, human α, β and γ polymerases themselves can copy DNA post pyrimidine dimers by inserting non complementary nucleotides.
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© 1977 Plenum Press, New York
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Villani, G., Defais, M., Spadari, S., Caillet-Fauquet, P., Boiteux, S., Radman, M. (1977). On the Molecular Mechanism of Mutagenesis by Carcinogenic Mutagens. In: Castellani, A. (eds) Research in Photobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4160-4_74
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DOI: https://doi.org/10.1007/978-1-4613-4160-4_74
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