Summary
2-6-diaminopurine (DAP), an analogue of adenine, selectively inhibited mitochondrial biogenesis in S. cerevisiae. This was detectable as failture of cytochromes aa 3 and b to develop leading to arrest of growth in non-fermentable medium. The analogue induced mitochondrial mutations to antibiotic resistance, particularly with respect to oligomycin and chloramphenicol, and to the petite condition. The efficiency of induction was strain dependent. DAP-treated cells when irradiated with UV light had a greatly enhanced rate of petite induction compared with either mutagen alone.
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© 1977 Plenum Press, New York
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Wallis, C., Wilkie, D. (1977). Mitochondrial mutagenesis by 2-6-diaminopurine in Saccharomyces cerevisiae: effect of UV light. In: Castellani, A. (eds) Research in Photobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4160-4_73
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DOI: https://doi.org/10.1007/978-1-4613-4160-4_73
Publisher Name: Springer, Boston, MA
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