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Mutagenic Repair Pathways in Yeast

  • R. C. von Borstel
  • P. J. Hastings

Abstract

In yeast, the RAD6 pathway has been shown to be involved in the induction of transitions. Three points of evidence indicate that yeast has another mutagenic repair pathway: 1) it is needed for induction of transversions; 2) some chemicals are still mutagenic in rad6; 3) the mutant rad6 is a mutator, presumably by channelling spontaneous lesions into another mutagenic repair pathway.

Since the two mutagenic repair pathways identified so far produce different predominant mutations, allele specificity in reversion studies can be used to distinguish the pathways.

Keywords

Repair Pathway Rad6 Strain Mutational Enzyme Spontaneous Mutation Rate Mutagenic Repair 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • R. C. von Borstel
    • 1
  • P. J. Hastings
    • 1
  1. 1.Department of GeneticsUniversity of AlbertaEdmontonCanada

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