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DNA Repair Schemes in Bacteria and in Human Cells

  • Philip C. Hanawalt

Abstract

This symposium on Repair of Radiation Damage deals with our current understanding of the various mechanisms by which living systems respond to damage in their genetic material. Most of the important discoveries in the field of DNA repair have resulted from the study of the response of cells to radiation. Also we know more about the repair of one particular type of ultraviolet light induced damage than any other. Ultraviolet light produces a variety of photo-products in DNA, intrastrand pyrimidine dimers being the most abundant. Dimers serve as model lesions for the study of DNA repair processes. An unrepaired dimer poses a block to normal DNA replication in vivo although replication may resume at a new initiation site beyond the dimer leaving a gap. Unless the dimers are removed or the post-replication gaps are filled the system becomes inviable.

Keywords

Xeroderma Pigmentosum WI38 Cell Pyrimidine Dimer Repair Synthesis Daughter Strand 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Philip C. Hanawalt
    • 1
  1. 1.Department of Biological SciencesStanford UniversityStanfordUSA

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