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Mass Spectrometry in Drug Metabolism pp 81–93Cite as

Identification of the N-Acetyl-β-Aryloxyalanines from Rats Treated with 3-(p-Tolyloxy)-1,2-Propanediol and 3-Phenoxy-1,2-Propanediol

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Summary

Using gas chromatography-mass spectrometry, N-acetyl-β-(p-tolyloxy)alanine was identified in the urine of rats treated with 3-(p-tolyloxy)-1,2-propanediol. Similary, N-acetyl-β-phenoxyalanine was identified in the urine of rats treated with 3-phenoxy-1,2-propanediol.

Thus the new metabolic conversion involving introduction of nitrogen which was found for the first time in the metabolism of Mephenesin, 3-(o-tolyloxy)-1,2-propanediol, was shown to occur also in the metabolism of the above two compounds.

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References

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Author information

Authors and Affiliations

  1. Kurume University School of Medicine, Kurume, Fukuoka, 830, Japan

    T. Kuhara, Y. Inoue & I. Matsumoto

Authors
  1. T. Kuhara
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  2. Y. Inoue
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  3. I. Matsumoto
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Editor information

Editors and Affiliations

  1. “Mario Negri” Institute for Pharmacological Research, Milan, Italy

    Alberto Frigerio

  2. Department of Organic Chemistry, University of Western Australia, Nedlands, Western Australia, Australia

    Emilio L. Ghisalberti

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© 1977 Plenum Press, New York

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Kuhara, T., Inoue, Y., Matsumoto, I. (1977). Identification of the N-Acetyl-β-Aryloxyalanines from Rats Treated with 3-(p-Tolyloxy)-1,2-Propanediol and 3-Phenoxy-1,2-Propanediol. In: Frigerio, A., Ghisalberti, E.L. (eds) Mass Spectrometry in Drug Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4151-2_7

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  • DOI: https://doi.org/10.1007/978-1-4613-4151-2_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4153-6

  • Online ISBN: 978-1-4613-4151-2

  • eBook Packages: Springer Book Archive

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