Binding of Haloalkanes to Liver Microsomes

  • Hartmut Uehleke

Abstract

During the past two decades, many investigations have shown that numerous toxic compounds are inert per se but are converted in the body to chemically reactive metabolites (1–3). The reactive metabolites or metabolic intermediates can combine with cellular constituents and may initiate methemoglobin formation (4–8), sensitization (9, 10), tumors (1), mutation (11, 12), lipid peroxidation (13, 14), or cellular necrosis (3, 15).

Keywords

Toxicity Chloroform Alkane NADPH Cytosol 

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Hartmut Uehleke
    • 1
  1. 1.Department of ToxicologyBundesgesundheitsamtBerlin 33Germany

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