Polycyclic Hydrocarbon Epoxides as Active Metabolic Intermediates
Many chemical carcinogens, including the polycyclic hydrocarbons, require metabolic activation before they can react with cellular macromolecules and probably before they can exert their biological effects (1). With the polycyclic hydrocarbons, this activation is carried out by both human and animal tissues, and the intermediates thus formed are believed to be epoxides (2). In this chapter, the overall metabolic pathways by which different types of epoxides are formed from polycyclic hydrocarbons, the routes by which these epoxides are further metabolized, and the structures of the epoxides that react with glutathione and probably with DNA in cells are considered.
KeywordsGlutathione Hydrocarbon Polycyclic Aromatic Hydrocarbon NADPH Pyrene
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