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Monoamine Oxidase, Monoamine-Oxidase-Inhibiting Drugs, and Human Behavior

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Handbook of Psychopharmacology

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Abstract

Monoamine-oxidase- (MAO)-inhibiting drugs, which reduce the oxidative deamination of the brain biogenic amine neurotransmitters, were the first effective antidepressant agents used in medicine. Although there have been many studies of the clinical efficacy of these agents, there have been only a handful of reports examining their other effects on human behavior and psychological function. There are also only a small number of studies of the effects of in vivo treatment with MAO-inhibiting drugs on human monoamine oxidase activity.

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  1. Clinical Neuropharmacology Branch, National Institute of Mental Health, Bethesda, Maryland, USA

    Dennis L. Murphy

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  1. Department of Pharmacology, University of Cambridge, UK

    Leslie L. Iversen

  2. Department of Psychology, University of Cambridge, UK

    Susan D. Iversen

  3. Departments of Pharmacology and Psychiatry, The Johns Hopkins University School of Medicine, USA

    Solomon H. Snyder

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© 1987 Plenum Press, New York

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Murphy, D.L. (1987). Monoamine Oxidase, Monoamine-Oxidase-Inhibiting Drugs, and Human Behavior. In: Iversen, L.L., Iversen, S.D., Snyder, S.H. (eds) Handbook of Psychopharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4045-4_2

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